Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti?biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities

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dc.authorid0000-0002-3524-0675en_US
dc.authorid0000-0001-8666-7954en_US
dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid57210429765en_US
dc.authorscopusid24472372400en_US
dc.authorscopusid6602001525en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorBhethanabotla, Venkat R.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2022-07-07T07:37:06Z
dc.date.available2022-07-07T07:37:06Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.description.abstractNanostructured fuorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The precursors citric acid (CA) and cysteine (Cys) were used in the preparation of S- and N-doped Cys carbon dots (Cys CDs). Synthesis was completed in 3 min. The graphitic structure revealed by XRD analysis of Cys CDs dots had good water dispersity, with diameters in the range of 2–20 nm determined by TEM analysis. The isoelectric point of the S, N-doped CDs was pH value for 5.2. The prepared Cys CDs displayed excellent fuorescence intensity with a high quantum yield of 75.6±2.1%. Strong antimicrobial capability of Cys CDs was observed with 12.5 mg/mL minimum bactericidal concentration (MBC) against gram-positive and gram-negative bacteria with the highest antimicrobial activity obtained against Staphylococcus aureus. Furthermore, Cys CDs provided total bioflm eradication and inhibition abilities against Pseudomonas aeruginosa at 25 mg/mL concentration. Cys CDs are promising antioxidant materials with 1.3±0.1 μmol Trolox equivalent/g antioxidant capacity. Finally, Cys CDs were also shown to inhibit the acetylcholinesterase (AChE) enzyme, which is used in the treatment of Alzheimer’s disease, even at the low concentration of 100 μg/mL.en_US
dc.identifier.citationSuner, S. S., Sahiner, M., Ayyala, R. S., Bhethanabotla, V. R., & Sahiner, N. (2021). Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities. Journal of Fluorescence, 31(6), 1705–1717. https://doi.org/10.1007/s10895-021-02798-xen_US
dc.identifier.doi10.1007/s10895-021-02798-x
dc.identifier.endpage1717en_US
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.issue6en_US
dc.identifier.pmid34424483
dc.identifier.scopus2-s2.0-85113814827
dc.identifier.startpage1705en_US
dc.identifier.urihttps://doi.org/10.1007/s10895-021-02798-x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3617
dc.identifier.volume31en_US
dc.identifier.wosWOS:000687518600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSağbaş Suner, Selin
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Fluorescenceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCysteine-based Carbon Dotsen_US
dc.subjectAntimicrobialen_US
dc.subjectAnti-biofilmen_US
dc.subjectAntioxidanten_US
dc.subjectAcetylcholinesterase Enzyme Inhibitoren_US
dc.titleVersatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti?biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities
dc.typeArticle

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