Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti?biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nanostructured fuorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The precursors citric acid (CA) and cysteine (Cys) were used in the preparation of S- and N-doped
Cys carbon dots (Cys CDs). Synthesis was completed in 3 min. The graphitic structure revealed by XRD analysis of Cys
CDs dots had good water dispersity, with diameters in the range of 2–20 nm determined by TEM analysis. The isoelectric
point of the S, N-doped CDs was pH value for 5.2. The prepared Cys CDs displayed excellent fuorescence intensity with
a high quantum yield of 75.6±2.1%. Strong antimicrobial capability of Cys CDs was observed with 12.5 mg/mL minimum bactericidal concentration (MBC) against gram-positive and gram-negative bacteria with the highest antimicrobial
activity obtained against Staphylococcus aureus. Furthermore, Cys CDs provided total bioflm eradication and inhibition
abilities against Pseudomonas aeruginosa at 25 mg/mL concentration. Cys CDs are promising antioxidant materials with
1.3±0.1 μmol Trolox equivalent/g antioxidant capacity. Finally, Cys CDs were also shown to inhibit the acetylcholinesterase
(AChE) enzyme, which is used in the treatment of Alzheimer’s disease, even at the low concentration of 100 μg/mL.
Açıklama
Anahtar Kelimeler
Cysteine-based Carbon Dots, Antimicrobial, Anti-biofilm, Antioxidant, Acetylcholinesterase Enzyme Inhibitor
Kaynak
Journal of Fluorescence
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
31
Sayı
6
Künye
Suner, S. S., Sahiner, M., Ayyala, R. S., Bhethanabotla, V. R., & Sahiner, N. (2021). Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities. Journal of Fluorescence, 31(6), 1705–1717. https://doi.org/10.1007/s10895-021-02798-x
