Reactivity of TNF-α, NF-κB, and TGF-β in Liver Tissue of Rats Due to the Sand Mussel Consumption

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dc.authoridÖztürk, Şamil / 0000-0002-9435-8139
dc.authoridİrkin, Latife Ceyda / 0000-0001-6603-8413
dc.contributor.authorÖztürk, Şamil
dc.contributor.authorİrkin, Latife Ceyda
dc.date.accessioned2025-01-27T20:35:02Z
dc.date.available2025-01-27T20:35:02Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
dc.description.abstractToxic substances such as heavy metals have been reported to accumulate by aquatic organisms. In this study, it was aimed to investigate the histopathological changes that may occur in the liver parenchyma, the largest gland of the digestive system, by feeding the rats with sand mussel. The samples were analyzed for cadmium (Cd), lead (Pb), copper (Cu), and zinc (Zn) by ICP-OES). The liver tissue samples were stained with Hematoxylin-Eosin (H&E), and immuohitochemically staining inflamatory marker TNF-α, NF-κB, and fibrotic factor TGF-β. Heavy metal accumulation in sand mussel tissue suggests that it may triggers the toxicity in tissues with the consumption frequently that the hepatotoxic effect was quite severe especially in rats fed with sand mussel. Also immunoreactivity of TNF-α, TGF-β and NF-κB were observed in the liver cells of especially second group. As a result, aquatic ecosystem can be affected with environmental pollution. It has been observed that crustaceans obtained from polluted ecosystems can cause especially digestive system organs damage in mammals.
dc.identifier.doi10.12681/jhvms.30199
dc.identifier.endpage5742
dc.identifier.issn1792-2720
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85165401419
dc.identifier.scopusqualityQ4
dc.identifier.startpage5735
dc.identifier.urihttps://doi.org/10.12681/jhvms.30199
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23552
dc.identifier.volume74
dc.identifier.wosWOS:001027992500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherHellenic Veterinary Medical Soc
dc.relation.ispartofJournal of The Hellenic Veterinary Medical Society
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectheavy metal
dc.subjecthepatotoxicity
dc.subjectapoptosis
dc.subjectsand mussel
dc.subjectrat
dc.titleReactivity of TNF-α, NF-κB, and TGF-β in Liver Tissue of Rats Due to the Sand Mussel Consumption
dc.typeArticle

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