Electrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds

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dc.authoridAY, Mehmet/0000-0002-1095-1614
dc.authoridGungor, Tugba/0000-0001-5261-1856
dc.authoridDilgin, Yusuf/0000-0002-2980-6871
dc.authoridComert Onder, Ferah/0000-0002-4037-1979
dc.contributor.authorSaglam, Ozlem
dc.contributor.authorComert Onder, Ferah
dc.contributor.authorGungor, Tugba
dc.contributor.authorAy, Mehmet
dc.contributor.authorDilgin, Yusuf
dc.date.accessioned2025-01-27T20:50:04Z
dc.date.available2025-01-27T20:50:04Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractVoltammetric behaviors of six nitro-substituted benzamides, which are potential prodrug candidates for nitroreductase-based cancer therapy, were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The electrochemical behavior of aromatic nitro (ArNO2) compounds by CV indicates that compounds involve various reduction/oxidation steps including the formation of aromatic nitro radical, nitroso, hydroxylamine, and amine groups. Applicability of the voltammetric determination of these prodrug candidates was studied by recording their DPVs, carried out in mixed media (Britton Robinson buffer solution + DMF) at various pH values on a pencil graphite electrode (PGE). Results show that the PGE can offer a disposable, low-cost, and sensitive electrochemical determination method for identifying nitro benzamide compounds. Under the experimental conditions, the PGE had a linear response range from 0.5 to 100 mu M 4-nitro- N-(2-nitrophenyl)benzamide (compound 2). This voltammetric procedure indicates that nitro-substituted benzamide drugs can be successfully determined in pharmaceutical samples.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK 1001) [110T754]; TUBITAK
dc.description.sponsorshipThis work was partially supported by the Scientific and Technological Research Council of Turkey (TUBITAK 1001, Grant No. 110T754). The authors wish to thank TUBITAK for this financial support.
dc.identifier.doi10.3906/kim-1705-51
dc.identifier.endpage+
dc.identifier.issn1300-0527
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85047933436
dc.identifier.scopusqualityQ3
dc.identifier.startpage780
dc.identifier.trdizinid374396
dc.identifier.urihttps://doi.org/10.3906/kim-1705-51
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/374396
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25399
dc.identifier.volume42
dc.identifier.wosWOS:000433980300015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectVoltammetry
dc.subjectpencil graphite electrode
dc.subjectnitro-substituted benzamide compounds
dc.titleElectrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds
dc.typeArticle

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