Unveiling Bone and Dental Regeneration Potential of Quince Seed Mucilage-Nanohydroxyapatite Scaffolds in Rabbit Mandibles

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dc.authoridCetin Genc, Cigdem/0000-0001-6745-3790
dc.contributor.authorGenc, Cigdem Cetin
dc.contributor.authorYilmaz-Dagdeviren, Hilal Deniz
dc.contributor.authorDeniz, Yesim
dc.contributor.authorDerkus, Burak
dc.contributor.authorDegirmenci, Alpin
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2025-05-29T02:58:10Z
dc.date.available2025-05-29T02:58:10Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDonor-side morbidity of autografting for maxillofacial region defect regeneration has directed attention to bioengineered scaffolds. Composite scaffolds that mimic the bone extracellular matrix (ECM) are the potential candidates for defect reconstruction. Herein, a plant-based regenerative hydrogel, quince seed mucilage (QSM), was enriched with the nanohydroxyapatite (nHAp) particles to construct composite scaffolds (QSM/nHAp). The emerging scaffold is able to induce cellular spheroid formation and regenerate the critical-sized bilateral mandibular defects in rabbits. The macroscopic observations, histochemical (HC) and immunohistochemical (IHC) stainings, mu-computer tomography (CT) scanning, quantitative real time-polymerase chain reaction (qRT-PCR) analyses, and scanning electron microscopy (SEM) imaging revealed that all QSM/nHAp scaffolds were swelled with host blood, filled the whole cavity, and sustained cellular infiltration without adverse reactions. The gradual biodegradation profile of the scaffolds improved bone regeneration by releasing nHAp particles from the scaffold. Strikingly, co-development of dental and bone regeneration was observed for all QSM/nHAp groups beginning after day 21. Moreover, QSM/nHAp scaffolds induced expression (> 2-fold) of bone and dental-related gene and protein expressions at the grafted area and sustained a proper platform for maxillofacial remodeling. Therefore, we strongly believe that such biocompatible plant-based constructs, compared with conventional medical devices used in maxillofacial surgery, could support and induce simultaneous bone and dental regeneration due to the intrinsic dynamics of the material.
dc.description.sponsorshipCanakkale Onsekiz Mart Universitesi
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart Universitesi.
dc.identifier.doi10.1002/jbm.b.35570
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue4
dc.identifier.pmid40145502
dc.identifier.scopus2-s2.0-105001919533
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jbm.b.35570
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30298
dc.identifier.volume113
dc.identifier.wosWOS:001454389200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biomedical Materials Research Part B-Applied Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectbone regeneration
dc.subjectcritical-size defect
dc.subjectdental regeneration
dc.subjectmaxillofacial surgery
dc.subjectnanohydroxyapatite
dc.subjectquince seed mucilage
dc.subjectrabbit
dc.titleUnveiling Bone and Dental Regeneration Potential of Quince Seed Mucilage-Nanohydroxyapatite Scaffolds in Rabbit Mandibles
dc.typeArticle

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