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Öğe Unveiling Bone and Dental Regeneration Potential of Quince Seed Mucilage-Nanohydroxyapatite Scaffolds in Rabbit Mandibles(Wiley, 2025) Çetin Genç, Çiğdem; Yılmaz-Dağdeviren, Hilal Deniz; Deniz, Yeşim; Derkuş, Burak; Değirmenci, Alpin; Arslan, Yavuz EmreDonor-side morbidity of autografting for maxillofacial region defect regeneration has directed attention to bioengineered scaffolds. Composite scaffolds that mimic the bone extracellular matrix (ECM) are the potential candidates for defect reconstruction. Herein, a plant-based regenerative hydrogel, quince seed mucilage (QSM), was enriched with the nanohydroxyapatite (nHAp) particles to construct composite scaffolds (QSM/nHAp). The emerging scaffold is able to induce cellular spheroid formation and regenerate the critical-sized bilateral mandibular defects in rabbits. The macroscopic observations, histochemical (HC) and immunohistochemical (IHC) stainings, mu-computer tomography (CT) scanning, quantitative real time-polymerase chain reaction (qRT-PCR) analyses, and scanning electron microscopy (SEM) imaging revealed that all QSM/nHAp scaffolds were swelled with host blood, filled the whole cavity, and sustained cellular infiltration without adverse reactions. The gradual biodegradation profile of the scaffolds improved bone regeneration by releasing nHAp particles from the scaffold. Strikingly, co-development of dental and bone regeneration was observed for all QSM/nHAp groups beginning after day 21. Moreover, QSM/nHAp scaffolds induced expression (> 2-fold) of bone and dental-related gene and protein expressions at the grafted area and sustained a proper platform for maxillofacial remodeling. Therefore, we strongly believe that such biocompatible plant-based constructs, compared with conventional medical devices used in maxillofacial surgery, could support and induce simultaneous bone and dental regeneration due to the intrinsic dynamics of the material.Öğe Effects of direct therapeutic radiation on pulpal surface of root dentin: an in vitro study(Springer Science and Business Media Deutschland GmbH, 2023) Deniz, Yeşim; Işıktaş Acar, Ezgi; Çetin Genç, ÇiğdemThe aims of the study were to analyze the effects of therapeutic radiation on human root dentin samples from the aspect of possible alterations in crystallinity, micro-morphology, and composition. Fifty-six root dentin specimens were divided into seven groups (0, 10, 20, 30, 40, 50, and 60 Gy). Scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) analyses were performed on pulpal surfaces of root dentin after being irradiated by 6MV photon energy. Mineral compositions, Ca/P, P/N, Ca/N ratios, and hydroxyapatite pikes were calculated. Some deuteriations on the dentin surface were observed in SEM images after 30 Gy and subsequent doses. One-way ANOVA revealed that there was no significant alteration in weight percentages of C, O, Mg, Ca, P, and N between groups. Radiation did not influence stoichiometric Ca/P, Ca/N, and P/N molar ratios. XRD analysis did not show a remarkable decline in hydroxyapatite pikes by the increasing doses. Radiotherapy changes the micromorphology of circumpulpal dentin but does not affect elemental composition and crystallinity.Öğe Accuracy of the radiographic methods of Willems, Cameriere and Blenkin-Evans on age estimation for Turkish children in the northwest Anatolia region(Taylor and Francis Ltd., 2021) Çarıkçıoğlu, Burak; Değirmenci, AlpinThe aim of this study is to compare the accuracy of the Willems Method (WM), Cameriere Method (CM) and Blenkin-Evans Method (BM) in the same study sample and determine which one is more suitable for Turkish population. This study included panoramic radiographs of 1024 individuals (619 boys and 585 girls) aged between 6.00 and 15.99 years. Dental age (DA) was calculated using WM, CM and BM for the total study sample, and separately, taking into account age groups and gender. Repeatability statistics evaluated with Cohen's Kappa test. The differences between chronological age (CA) and the DA were statistically tested using a paired sample t-test and the Wilcoxon signed-rank test. WM overestimated the CA by 0.23 years, while both CM and BM underestimated it by 0.51 and 0.05 years, respectively. In all samples, the DA-CA difference was significant in all methods with one exception BM in boys. Although WM and BM both seem satisfactory in age estimation for children at the northwest Anatolia region of Turkey, BM performs slightly better than CM and it has shown the most accurate results except for the 15 year age group.
