Synthesis and characterization of biodegradable and antioxidant phosphazene-tannic acid nanospheres and their utilization as drug carrier material

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dc.authorid0000-0002-0775-0053en_US
dc.authorid0000-0002-4184-7801en_US
dc.authorscopusid44661551800en_US
dc.authorscopusid35102910700en_US
dc.authorwosidAAA-2056-2020en_US
dc.authorwosidIXD-2153-2023en_US
dc.contributor.authorÖnder, Alper
dc.contributor.authorÖzay, Hava
dc.date.accessioned2025-02-10T07:26:33Z
dc.date.available2025-02-10T07:26:33Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractIn this study, hexachlorocyclotriphosphazene (HCCP) and tannic acid (TA) were used at different stoichiometric ratios to synthesize cyclomatrix-type polymeric materials with different surface features and dimensions. Using different reactive ratios, the structure and surface functional groups of the synthesized polymeric particles were explained using Fourier-Transform Infrared Spectroscopic (FTIR), Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray Photoelectron Spectroscopy (XPS) and Thermogravimetric (TG) analysis techniques. With morphologically fully spherical structure and mean 234.82 ± 49.37 nm dimensions, Phz-TA (4:1) nanospheres were researched for in vitro biodegradability, antioxidant features, and usability as a drug release system. In vitro biodegradability of Phz-TA (4:1) nanospheres was investigated at pH = 7.0 and pH = 1.2. Determined to degrade in 8–10 h at these pH values, nanospheres were used for releasing of Rhodamine 6G as a model drug. Due to the rich phenolic structure of the contained tannic acid units, nanospheres were determined to simultaneously have antioxidant features. Thus, this study determined that Phz-TA nanospheres with in vitro biodegradability and antioxidant features are promising polymeric materials for use as a potential drug-carrier in the future.en_US
dc.identifier.citationÖnder, A., & Özay, H. (2021). Synthesis and characterization of biodegradable and antioxidant phosphazene-tannic acid nanospheres and their utilization as drug carrier material. Materials Science and Engineering: C, 120, 111723. https://doi.org/10.1016/j.msec.2020.111723en_US
dc.identifier.doi10.1016/j.msec.2020.111723en_US
dc.identifier.issn0928-4931 / 1873-0191
dc.identifier.pmidPMID: 33545874en_US
dc.identifier.scopus2-s2.0-85096823867en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.msec.2020.111723
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29597
dc.identifier.volume120en_US
dc.identifier.wosWOS:000617983800003en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖnder, Alper
dc.institutionauthorÖzay, Hava
dc.institutionauthorid0000-0002-0775-0053
dc.institutionauthorid0000-0002-4184-7801
dc.language.isoengen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Science and Engineering Cen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiodegradableen_US
dc.subjectBiomaterialen_US
dc.subjectDrug deliveryen_US
dc.subjectNanosphereen_US
dc.subjectPhosphazeneen_US
dc.subjectTannic aciden_US
dc.titleSynthesis and characterization of biodegradable and antioxidant phosphazene-tannic acid nanospheres and their utilization as drug carrier materialen_US
dc.typearticleen_US

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