Bone tissue engineering for osteointegration: Where are we now?

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dc.contributor.authorAykora, Damla
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:56:10Z
dc.date.available2025-01-27T20:56:10Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBone fracture healing is a challenging process, due to insufficient and slow tissue repair. Sufferers from bone fractures struggle with one-third of nonunion, display graft rejection, high-costed implantation, or chronic pain. Novel advances in tissue engineering presented promising options for this strain. Biomaterials for bone repair allow accelerated regeneration, osteoblastic cell activation, and enhanced bone remodeling. There is a wide range of biomaterials that are biocompatible, bioresorbable, and biodegradable and used for bone tissue regeneration, promoting osteoconductive and osteoinductive properties. The main aim of bone tissue engineering is to generate rapid and optimal functional bone regeneration through a combination of biomaterials, growth factors, cells, and various agents. Recently bone tissue engineering has been attracted to the use of bioactive glass scaffolds incorporated with polymers and patient-specific fabrication of the bone healing material by 3D bioprinting. There are promising future outcomes that were reported by several research. The present review provides an outlook for recent most common biomaterials in bone tissue engineering suggesting bone tissue engineering practices should have been proceeded to clinical application.
dc.description.sponsorshipCanakkale Onsekiz Mart University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s00289-024-05153-9
dc.identifier.endpage8605
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85183786656
dc.identifier.scopusqualityQ1
dc.identifier.startpage8595
dc.identifier.urihttps://doi.org/10.1007/s00289-024-05153-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26326
dc.identifier.volume81
dc.identifier.wosWOS:001156026600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBone healing
dc.subjectBiomaterial
dc.subjectBone tissue engineering
dc.subjectBioactive glass scaffold
dc.subjectPolymer
dc.titleBone tissue engineering for osteointegration: Where are we now?
dc.typeReview Article

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