Gallic Acid Induces HeLa Cell Lines Apoptosis via the P53/Bax Signaling Pathway

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dc.authoridTuncer, Mehmet Cudi/0000-0001-7317-5467
dc.contributor.authorSari, Umut
dc.contributor.authorZaman, Fuat
dc.contributor.authorOzdemir, Ilhan
dc.contributor.authorOzturk, Samil
dc.contributor.authorTuncer, Mehmet Cudi
dc.date.accessioned2025-01-27T20:24:26Z
dc.date.available2025-01-27T20:24:26Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Cervical cancer is a type of cancer that originates from the endometrium and is more common in developed countries and its incidence is increasing day by day in developing countries. The most commonly prescribed chemotherapeutic drugs limit their use due to serious side effects and the development of drug resistance. For this reason, interest in new active ingredients obtained from natural products is increasing. This study aimed to reveal the apoptotic and antiproliferative effects of gallic acid and doxorubicin combination therapy against the HeLa cell line. Methods: We investigated the anti-cancer effects of doxorubicin and gallic acid in the human HeLa cervical cell line by using the MTT test, Nucblue staining for the identification of apoptotic cells due to nuclear condensation using fluorescent substance, and apoptotic markers P53 and Bax for the RT-PCR test. Results: The highest cytotoxic effect obtained in the study, the highest increase in apoptotic induction, and a significant difference in P53/Bax levels were seen in the gallic acid/doxorubicin combination. Additionally, it was determined that gallic acid exhibited an effective cytotoxic effect on HeLa and HaCat cells within 48 and 72 h of application. Conclusions: The obtained findings show that the gallic acid/doxorubicin combination applied to HeLa cells may be an alternative treatment against both the cytotoxic effect size and the side effects of the chemotherapy agent.
dc.identifier.doi10.3390/biomedicines12112632
dc.identifier.issn2227-9059
dc.identifier.issue11
dc.identifier.pmid39595196
dc.identifier.scopus2-s2.0-85210427317
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/biomedicines12112632
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22220
dc.identifier.volume12
dc.identifier.wosWOS:001366863500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofBiomedicines
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectcervical cancer
dc.subjectcytotoxicty
dc.subjectdoxorubicin
dc.subjectanticancer
dc.subjectnatural products
dc.titleGallic Acid Induces HeLa Cell Lines Apoptosis via the P53/Bax Signaling Pathway
dc.typeArticle

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