Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein

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dc.authoridÇam, Mustafa / 0000-0003-3116-203X
dc.contributor.authorKoç, Sümeyye
dc.contributor.authorŞen, Sedat
dc.contributor.authorTerzi, Yüksel
dc.contributor.authorKızılay, Ferah
dc.contributor.authorDemir, Serkan
dc.contributor.authorBekar Aksoy, Dürdane
dc.contributor.authorKurtuluş, Fatma
dc.contributor.authorÇam, Mustafa
dc.date.accessioned2025-01-27T20:45:41Z
dc.date.available2025-01-27T20:45:41Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University's Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
dc.identifier.doi10.4274/balkanmedj.galenos.2024.2024-1-97
dc.identifier.endpage279
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4
dc.identifier.pmid38828767
dc.identifier.scopus2-s2.0-85197994337
dc.identifier.scopusqualityQ1
dc.identifier.startpage272
dc.identifier.trdizinid1273590
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2024.2024-1-97
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1273590
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24683
dc.identifier.volume41
dc.identifier.wosWOS:001267760500006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTrakya University School of Medicine
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.titleClinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
dc.typeArticle

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