Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model?

Basit Öğe Kaydı
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorMemi, Gulsun
dc.contributor.authorKaner, Tuncay
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorSahin, Onder
dc.contributor.authorGuven, Mustafa
dc.contributor.authorCosar, Murat
dc.date.accessioned2025-01-27T20:32:07Z
dc.date.available2025-01-27T20:32:07Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground/aim: To investigate the neuroprotective effects of glucagon-like peptide 2 (Glp-2), which increases cerebral blood flow, on the hippocampal complex after cerebral ischemia/reperfusion (I/R) injury in rats. Materials and methods: Animals were randomized into 4 groups: sham, I/R + 0.9% NaCl, I/R + pre-Glp-2, and I/R + post-Glp-2. Cerebral ischemia was performed via the occlusion of the bilateral internal carotid artery for 40 min and continued with a reperfusion process. At the end of 6 h of reperfusion, animals were decapitated in all groups and brain tissues were removed. Malondialdehyde (MDA) and natural intracellular antioxidant glutathione (GSH) levels and myeloperoxidase (MPO) activities were measured in the left hippocampal tissue. The right hippocampal tissues of all group members were taken for histopathologic study. Results: MDA levels and MPO activities increased from Group I to Group II and decreased from Group II to Groups III and IV. On the other hand, GSH levels were not significantly different among the groups. The number of apoptotic hippocampal tissue cells increased from Group I to Group II and decreased from Group II to Groups III and IV. Conclusion: Our preliminary study revealed that Glp-2 treatment may decrease oxidative damage from I/R in cerebral tissue.
dc.identifier.doi10.3906/sag-1402-64
dc.identifier.endpage473
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3
dc.identifier.pmid26281308
dc.identifier.scopus2-s2.0-84929757256
dc.identifier.scopusqualityQ1
dc.identifier.startpage467
dc.identifier.trdizinid172629
dc.identifier.urihttps://doi.org/10.3906/sag-1402-64
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/172629
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23356
dc.identifier.volume45
dc.identifier.wosWOS:000356357800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectReperfusion injury
dc.subjectglucagon-like peptide 2
dc.subjectneuroprotective effect
dc.subjectrats
dc.titleDoes Glp-2 have a protective effect on cerebral ischemia/reperfusion model?
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu