Relationship of QT dispersion with sex hormones and insulin in young women with polycystic ovary syndrome: an observational study

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dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.contributor.authorGazi, Emine
dc.contributor.authorGencer, Meryem
dc.contributor.authorHanci, Volkan
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorAltun, Burak
dc.contributor.authorGungor, Ayse Nur Cakir
dc.contributor.authorOzturk, Ufuk
dc.date.accessioned2025-01-27T21:02:15Z
dc.date.available2025-01-27T21:02:15Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in reproductive women. Cardiovascular disease risk factors are more frequent in this population. We aimed in this study to investigate presence of QT dispersion and effects of sex hormones and insulin on QT duration in young PCOS patients. Methods: This present study was cross-sectional observational study. A total of 47 women, 25 patients with PCOS and 22 healthy, were included. Serum testosterone, estradiol and insulin levels were studied and electrocardiography was performed at 2nd or 3th days of menstrual cycle. The study population was divided into groups according to serum testosterone and estradiol levels. Sub-groups and pairwise groups were compared by Mann-Whitney U or student t-test. The associations of QTc durations with hormone levels were calculated using Spearman rank correlation analysis. The results were evaluated at the p<0.05 significance level. Results: No differences found between groups regarding to demographic parameters. Estradiol and testosterone levels were higher in patients with PCOS (41.12 +/- 13.59 vs. 35.57 +/- 19.29 pg/mL, p=0.09 and 105 +/- 58.5 vs. 17.6 +/- 10.9 ng/dL, p=0.01, respectively). QT dispersion was significantly longer in PCOS patients (47.1 vs. 32.7 ms, p=0.01). A positive correlation was found between the serum insulin level and QTc min, QTc max, and QTc mean (r=0.402, p=0.011; r=0.341, p=0.033; r=0.337, p=0.036; respectively). QT dispersion with serum testosterone and estradiol levels were positively correlated (r=0.525, p=0.001and r=0.326, p=0.046; respectively). Conclusion: Our results suggest that QT dispersion is prolonged and testosterone, estradiol and insulin are associated with QT duration in young PCOS patients.
dc.identifier.doi10.5152/akd.2013.264
dc.identifier.endpage777
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue8
dc.identifier.pmid24172835
dc.identifier.scopus2-s2.0-84890394984
dc.identifier.scopusqualityN/A
dc.identifier.startpage772
dc.identifier.trdizinid155642
dc.identifier.urihttps://doi.org/10.5152/akd.2013.264
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/155642
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27321
dc.identifier.volume13
dc.identifier.wosWOS:000328880000010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectElectrocardiography
dc.subjectQT dispersion
dc.subjectpolycystic ovary syndrome
dc.subjectinsulin resistance
dc.subjectinsulin
dc.titleRelationship of QT dispersion with sex hormones and insulin in young women with polycystic ovary syndrome: an observational study
dc.title.alternativePolikistik over sendromu olan genç kadi{dotless}nlarda QT dispersiyonu ile gonadal hormonlar ve insulin arasi{dotless}ndaki ilişki: Gözlemsel bir çali{dotless}şma
dc.typeArticle

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