Unraveling the role of Globularia species in modern medicine based on evidence from photochemistry, traditional uses and biological activities

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorEl-Seedi, Hesham R.
dc.contributor.authorSabry, Aya
dc.contributor.authorAbolibda, Tariq Z.
dc.contributor.authorGuo, Zhiming
dc.contributor.authorNahar, Lütfun
dc.contributor.authorSarker, Satyajit D.
dc.contributor.authorSaeed, Aamer
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-05-29T02:57:57Z
dc.date.available2025-05-29T02:57:57Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Species of the genus Globularia exist in the Mediterranean region spreading upon Macaronesia, northern Europe, and north-eastern Africa. They have valuable biological activities and remarkable phytochemical contents explaining their traditional uses. Purpose: This study reviews phytochemical, pharmacological progress, clinical trials, and molecular mechanisms of action of Globularia extracts and isolated compounds. Study design: In this review the systematic approach is used in summarizing and documenting the information related to Globularia extracts with a special focus on the bioactive component that have numerous biological activities and modes of action. Methods: The relevant information related to the genus Globularia was collected from different databases (SciFinder, Elsevier, PubMed, and Google Scholar) as well as the clinical trials website (https://clinicaltrials.gov/). Results: The genus Globularia consists of 22 species that are used in traditional medicine as laxative, cholagogue, stomachic, purgative, sudorific, antihypertensive, hypoglycemic, carminative, diuretic, and tonic agents. The extracts of these species have biological potentials, for instance, antioxidant, anti-inflammatory, anti-coagulant, anti-diabetes, anti-bacterial, anti-tuberculosis, enzyme inhibitors, wound healing, toxicological, and neuroprotective activity. Among the valuable bioactive phytochemicals are iridoid glycosides, phenylethanoids, and flavonoid glycosides. Conclusion: Despite the efforts made in Globularia isolation there is a lack of knowledge of the biological role of the isolated compounds. Also, the traditional uses of Globularia species are not well-explored and the mechanisms of actions are not investigated thus opening new doors for future efforts in this line.
dc.description.sponsorshipZhenjiang Science & Technology Program [GJ2024009]
dc.description.sponsorshipThis research was funded by the Zhenjiang Science & Technology Program (Grant No GJ2024009) .
dc.identifier.doi10.1016/j.phymed.2025.156466
dc.identifier.issn0944-7113
dc.identifier.issn1618-095X
dc.identifier.pmid39951969
dc.identifier.scopus2-s2.0-85217673905
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.phymed.2025.156466
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30210
dc.identifier.volume139
dc.identifier.wosWOS:001427746000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofPhytomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectGlobularia
dc.subjectTraditional uses
dc.subjectClinical trials
dc.titleUnraveling the role of Globularia species in modern medicine based on evidence from photochemistry, traditional uses and biological activities
dc.typeArticle

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