Enhancing nutritional health and patient satisfaction five years after metabolic bariatric surgery with targeted supplementation

dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorGorini, Stefania
dc.contributor.authorCamajani, Elisabetta
dc.contributor.authorFranchi, Arianna
dc.contributor.authorCava, Edda
dc.contributor.authorGentileschi, Paolo
dc.contributor.authorBellia, Alfonso
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-05-29T02:57:38Z
dc.date.available2025-05-29T02:57:38Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground This study analyzes the long-term outcomes of metabolic bariatric surgery (MBS), focusing on weight loss, nutritional deficiencies, and patient satisfaction. We evaluate different surgical techniques to identify their impact on these outcomes. Methods A five-year retrospective analysis was conducted on 249 patients who underwent MBS at a specialized center. Baseline characteristics included an average age of 38.5 years, weight of 118.5 kg, and BMI of 43.2 kg/m(2). Weight loss outcomes were assessed using mean excess weight loss (%EWL) at 60 months. Surgical techniques included laparoscopic sleeve gastrectomy (LSG), one anastomosis gastric bypass (OAGB), and Roux-en-Y gastric bypass (RYGB). Nutritional deficiencies and patient-reported quality of life were also evaluated. Results The mean %EWL at 60 months was 92.1% +/- 25.8% (p = 0.013). While LSG and OAGB showed similar weight loss patterns, RYGB resulted in further weight reduction from the third year onwards. Patients revised from LSG to RYGB had significantly greater weight loss (102.1%) compared to those revised to mini-gastric bypass (MGB) (84.6%, p < 0.05). Nutritional deficiencies were prevalent, with 41.2% of revised LSG patients experiencing iron deficiency and 14.3% developing new vitamin D deficiencies (p < 0.05). Most patients (85%) reported improvements in quality of life, and 85% expressed a willingness to undergo surgery again (p = 0.0028). Conclusions MBS resulted in substantial and sustained weight loss, particularly in RYGB patients. Surgical revisions, especially from LSG to RYGB, were associated with greater weight loss but also increased nutritional risks. Persistent iron and vitamin D deficiencies highlight the necessity of individualized supplementation and long-term monitoring. Type-targeted supplementation represents an innovative approach to optimizing long-term nutritional support in bariatric patients. Future studies with larger cohorts and validated tools are needed to confirm these findings and strengthen clinical guidelines.
dc.description.sponsorshipMIUR [202285HFZY]; Institutional funding of the Italian Ministry of Health (Ricerca Corrente)
dc.description.sponsorshipThis manuscript was funded by the MIUR (Progetti di Ricerca di Interesse Nazionale 2022-Project code 202285HFZY -to MC, Work Package Leader), and by Institutional funding of the Italian Ministry of Health (Ricerca Corrente).
dc.identifier.doi10.1186/s12967-025-06224-9
dc.identifier.issn1479-5876
dc.identifier.issue1
dc.identifier.pmid39984967
dc.identifier.scopus2-s2.0-85218495002
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12967-025-06224-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30111
dc.identifier.volume23
dc.identifier.wosWOS:001428408500003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofJournal of Translational Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectMetabolic bariatric surgery
dc.subjectNutritional health
dc.subjectTargeted supplementation
dc.subjectLong-term weight maintenance
dc.subjectPatient satisfaction
dc.subjectRoux-en-Y gastric bypass
dc.subjectSleeve gastrectomy
dc.subjectPersonalized nutrition
dc.subjectPostoperative outcomes
dc.subjectBariatric supplementation
dc.titleEnhancing nutritional health and patient satisfaction five years after metabolic bariatric surgery with targeted supplementation
dc.typeArticle

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