Serum Fetuin-A Level in Patients With Ankylosing Spondylitis and its Relationship With Clinical Parameters

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dc.contributor.authorGokmen, Ferhat
dc.contributor.authorAkbal, Ayla
dc.contributor.authorGunes, Fahri
dc.contributor.authorTurkon, Hakan
dc.contributor.authorVural, Ahmet
dc.contributor.authorBinnetoglu, Emine
dc.contributor.authorKomurcu, Erkam
dc.date.accessioned2025-01-27T20:14:58Z
dc.date.available2025-01-27T20:14:58Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study aims to investigate the association of serum fetuin-A levels with disease activation and clinical parameters in ankylosing spondylitis (AS) patients. Patients and methods: Forty-seven AS patients (30 males, 17 females; mean age 39.7 +/- 11.1 years; range 20 to 69 years) and 30 healthy controls (14 males, 16 females; mean age 42.0 +/- 11.5 years; range 19 to 63 years) were included in the study. Erythrocyte sedimentation rate, C-reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Radiology Index, and Bath Ankylosing Spondylitis Metrology Index were used in the assessment of AS. Serum fetuin-A levels were measured using ELISA. Results: Mean serum fetuin-A values in AS patients (984 +/- 203 ng/mL) were significantly lower compared to controls (1156 +/- 218 ng/mL) (p=0.001). While a statistically significant negative correlation was detected in AS patients between fetuin-A values and C-reactive protein (p=0.009, r=-0.377), no significant correlation was detected between erythrocyte sedimentation rate, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Functional Index or Bath Ankylosing Spondylitis Radiology Index parameters and fetuin-A. Conclusion: Serum fetuin-A levels in AS patients were lower than the control group. However, further research is required to establish the role of serum fetuin-A levels as a surrogate marker of disease activity.
dc.identifier.doi10.5606/ArchRheumatol.2015.5061
dc.identifier.endpage5
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84926372842
dc.identifier.scopusqualityN/A
dc.identifier.startpage1
dc.identifier.trdizinid168591
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2015.5061
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/168591
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21247
dc.identifier.volume30
dc.identifier.wosWOS:000352060500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish League Against Rheumatism
dc.relation.ispartofArchives of Rheumatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute phase reactants
dc.subjectankylosing spondylitis
dc.subjectfetuin-A
dc.titleSerum Fetuin-A Level in Patients With Ankylosing Spondylitis and its Relationship With Clinical Parameters
dc.typeArticle

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