The Effect of Smoking on Corneal Endothelial Cells

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dc.contributor.authorKara, Selcuk
dc.contributor.authorGencer, Baran
dc.contributor.authorTurkon, Hakan
dc.contributor.authorErsan, Ismail
dc.contributor.authorEkim, Yeliz Ozkanoglu
dc.contributor.authorArikan, Sedat
dc.contributor.authorTufan, Hasan Ali
dc.date.accessioned2025-01-27T20:48:08Z
dc.date.available2025-01-27T20:48:08Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To investigate the effect of chronic cigarette smoking on the endothelial cells of the cornea via non contact specular microscopy. Method: In this prospective, cross-sectional study, 25 eyes of 25 chronic smokers and 21 eyes of 21 age-matched, healthy non-smokers were enrolled. The Fagerstrom Test for Nicotine Dependence on Cigarettes was used to determine the nicotine dependency level. The level of cotinine, a major metabolite of nicotine, was measured in urine samples from the control group to detect whether they were passively affected by cigarette smoke. All participants underwent measurement of tear break-up time (TBUT), central corneal thickness (CCT), and axial length. Endothelial cell density and endothelial cell morphology were evaluated by non-contact specular microscopy. Results: On average, the cigarette smokers consumed 19.2 +/- 8.3 cigarettes per day and had been smoking for 14.5 +/- 6.8 years. The mean TBUT value was significantly lower in the smoker group compared to the non-smoker group (p<0.05). No statistically significant difference was found in the mean CCT, mean endothelial cell density, or parameters of endothelial cell morphology between smokers and non-smokers. Conclusion: This study showed that cigarette smoking seems to affect the TBUT value but no effects were found on the parameters of corneal endothelial cells.
dc.description.sponsorshipScientific Research Projects Commission of Canakkale Onsekiz Mart University [TSA-2013-182]
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Commission of Canakkale Onsekiz Mart University, project number TSA-2013-182.
dc.identifier.doi10.3109/08820538.2015.1053626
dc.identifier.endpage227
dc.identifier.issn0882-0538
dc.identifier.issn1744-5205
dc.identifier.issue2
dc.identifier.pmid26291647
dc.identifier.scopus2-s2.0-84939504545
dc.identifier.scopusqualityQ2
dc.identifier.startpage223
dc.identifier.urihttps://doi.org/10.3109/08820538.2015.1053626
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25148
dc.identifier.volume32
dc.identifier.wosWOS:000394725400013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofSeminars in Ophthalmology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCentral corneal thickness
dc.subjectcigarette
dc.subjectcornea endothelium
dc.subjectcotinine
dc.subjectspecular microscopy
dc.titleThe Effect of Smoking on Corneal Endothelial Cells
dc.typeArticle

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