The Effect of Smoking on Corneal Endothelial Cells
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To investigate the effect of chronic cigarette smoking on the endothelial cells of the cornea via non contact specular microscopy. Method: In this prospective, cross-sectional study, 25 eyes of 25 chronic smokers and 21 eyes of 21 age-matched, healthy non-smokers were enrolled. The Fagerstrom Test for Nicotine Dependence on Cigarettes was used to determine the nicotine dependency level. The level of cotinine, a major metabolite of nicotine, was measured in urine samples from the control group to detect whether they were passively affected by cigarette smoke. All participants underwent measurement of tear break-up time (TBUT), central corneal thickness (CCT), and axial length. Endothelial cell density and endothelial cell morphology were evaluated by non-contact specular microscopy. Results: On average, the cigarette smokers consumed 19.2 +/- 8.3 cigarettes per day and had been smoking for 14.5 +/- 6.8 years. The mean TBUT value was significantly lower in the smoker group compared to the non-smoker group (p<0.05). No statistically significant difference was found in the mean CCT, mean endothelial cell density, or parameters of endothelial cell morphology between smokers and non-smokers. Conclusion: This study showed that cigarette smoking seems to affect the TBUT value but no effects were found on the parameters of corneal endothelial cells.
Açıklama
Anahtar Kelimeler
Central corneal thickness, cigarette, cornea endothelium, cotinine, specular microscopy
Kaynak
Seminars in Ophthalmology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
32
Sayı
2
