Elevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target?

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dc.authorid0000-0003-3560-849Xen_US
dc.authorid0000-0003-2777-341Xen_US
dc.authorid0000-0003-4436-9160en_US
dc.authorid0000-0002-6269-5990en_US
dc.authorscopusid56924708500en_US
dc.authorscopusid57391820300en_US
dc.authorscopusid57221785513en_US
dc.authorscopusid57205330862en_US
dc.authorwosidAAK-4705-2020en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorKılıç, Sevilay
dc.contributor.authorMermutlu, Selda I.
dc.contributor.authorŞehitoglu, Hilal
dc.contributor.authorEkinci, Alper
dc.date.accessioned2023-06-19T11:04:54Z
dc.date.available2023-06-19T11:04:54Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground: Rosacea is a chronic inflammatory skin disease whose etiopathogenesis is still unknown. Previous studies have shown a relationship between certain inflammatory disorders and serum endocan levels. Endocan (previously known as endothelial cell-specific molecule 1) might play a role in the pathogenesis of various inflammatory diseases. Aims and Objectives: Our study aimed to evaluate serum endocan levels in patients with rosacea to investigate the association of endocan with the demographic data. Materials and Methods: The study recruited individuals aged ≥18 years who voluntarily agreed to participate in the study. The participants included 37 women (mean age: 48.29 ± 12.08 years) and 13 men (mean age: 52.23 ± 13.34 years) diagnosed with rosacea, and 37 women (mean age: 49.18 ± 16.6 years) and 13 men (mean age: 53.69 ± 11.30 years) selected as controls. Both groups were matched according to age and sex. The rosacea diagnosis was based on clinical examination findings, and serum endocan levels were measured using the method of enzyme-linked immunosorbent assay (ELISA). The statistical significance of the data was determined by the Mann-Whitney U test, and a value of P < 0.05 was considered statistically significant. Results: Serum endocan levels differed significantly between the patients with rosacea and the control group (P < 0.05). Conclusion: Circulating endocan might be a new marker related to disease progression in patients with rosacea. Further investigation is needed to determine whether endocan levels could become a new therapeutic target in rosacea, a disease that still cannot be fully cured.en_US
dc.identifier.citationKılıç, S., Mermutlu, S. I., Şehitoǧlu, H., & Ekinci, A. (2021). Elevated serum endocan levels in patients with rosacea: A new therapeutic target? Indian Journal of Dermatology, 66(5), 520-524. doi:10.4103/ijd.ijd_401_21en_US
dc.identifier.doi10.4103/ijd.ijd_401_21
dc.identifier.endpage524en_US
dc.identifier.issn0019-5154
dc.identifier.issn1998-3611
dc.identifier.issue5en_US
dc.identifier.pmid35068507
dc.identifier.scopus2-s2.0-85122026796
dc.identifier.startpage520en_US
dc.identifier.urihttps://doi.org/10.4103/ijd.ijd_401_21
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4315
dc.identifier.volume66en_US
dc.identifier.wosWOS:000756582500012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKılıç, Sevilay
dc.institutionauthorMermutlu, Selda I.
dc.institutionauthorŞehitoğlu, Hilal
dc.institutionauthorEkinci, Alper
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndocanen_US
dc.subjectESM-1en_US
dc.subjectInflammationen_US
dc.subjectRosaceaen_US
dc.titleElevated Serum Endocan Levels in Patients with Rosacea: A New Therapeutic Target?
dc.typeArticle

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