Quercetin, a powerful antioxidant bioflavonoid, attenuates renal dysfunction in long-term experimental diabetes mellitus

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dc.contributor.authorEdremitliolu, Mustafa
dc.contributor.authorAndic, Mehmet Fatih
dc.contributor.authorSayin, Derya Beyza
dc.contributor.authorKorkut, Oguzhan
dc.contributor.authorKisa, Ucler
dc.date.accessioned2025-01-27T21:21:19Z
dc.date.available2025-01-27T21:21:19Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: Diabetes mellitus (DM) can cause serious complications such as nephropathy in long term. One of the factors of diabetic nephropathy pathogenesis is the increase of oxidant stress. The aim of this study is to examine the effect of quercetin, a powerful antioxidant agent, on renal functions in streptozotocin-induced diabetes mellitus and the change in balance of oxidant-antioxidant capacity in this process. Methods: Five groups of rats were used: Control, DM 8 and 16-week (DM8, DM16), DM 8 and 16-week + quercetin (QUER8, QUER16). Rats in QUER8 and QUER1 6 were treated with IP quercetin (15 mg/kg/day) until the end of the experiment. Results: Malondialdehyte increased in the DM8 and DM16 groups. On the contrary, it decreased in the groups which were given quercetin. Accordingly, increase in NADPH oxidase activity, and decrease in superoxide dismutase and catalase activities in diabetic rats were determined. In the QUER8 and QUER16 groups, NADPH oxidase activity decreased while antioxidant enzyme activities increased. Functional kidney parameters were considerably corrupted in the diabetic rats. Sodium and water excretion via urine and plasma creatinine level in the QUER16 group were lower than in the DM16 group. Conclusion: These findings suggest that the administration of quercetin attenuated renal dysfunction and totally prevented the increase of kidney oxidant damage in DM.
dc.description.sponsorshipKirikkale University Scientific Research Projects Commission [2005/25]
dc.description.sponsorshipThis work was supported by the Kirikkale University Scientific Research Projects Commission (2005/25).
dc.identifier.doi10.5472/MMJ.2011.01863.1
dc.identifier.endpage99
dc.identifier.issn1309-9469
dc.identifier.issue2
dc.identifier.scopus2-s2.0-79960415191
dc.identifier.scopusqualityQ4
dc.identifier.startpage88
dc.identifier.trdizinid128350
dc.identifier.urihttps://doi.org/10.5472/MMJ.2011.01863.1
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/128350
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28894
dc.identifier.volume24
dc.identifier.wosWOS:000219993700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ, Fac Medicine
dc.relation.ispartofMarmara Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectQuercetin
dc.subjectDiabetes mellitus
dc.subjectNephropathy
dc.subjectOxidative damage
dc.subjectAntioxidant enzymes
dc.subjectNADPH oxidase
dc.titleQuercetin, a powerful antioxidant bioflavonoid, attenuates renal dysfunction in long-term experimental diabetes mellitus
dc.title.alternativeGüçlü bir antioksidan bioflavonoid olan quercetin uzun süreli deneysel diabetes mellitustaki böbrek fonksiyon bozuklu?unu azaltir
dc.typeArticle

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