RNA modifications as emerging therapeutic targets

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dc.authorid0000-0002-2014-6635en_US
dc.authorscopusid22733342800en_US
dc.authorwosid-en_US
dc.contributor.authorÇayır, Akın
dc.date.accessioned2024-12-12T05:57:58Z
dc.date.available2024-12-12T05:57:58Z
dc.date.issued2021en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractThe field of epitranscriptome, posttranscriptional modifications to RNAs, isstill growing up and has presented substantial evidences for the role of RNAmodifications in diseases. In terms of new drug development, RNA modifica-tions have a great promise for therapy. For example, more than 170 type ofmodifications exist in various types of RNAs. Regulatory genes and their rolesin critical biological process have been identified and they are associated withseveral diseases. Current data, for example, identification of inhibitorstargeting RNA modifications regulatory genes, strongly support the idea thatRNA modifications have potential as emerging therapeutic targets. Therefore,in this review, RNA modifications and regulatory genes were comprehensivelydocumented in terms of drug development by summarizing the findings fromprevious studies. It was discussed how RNA modifications or regulatory genescan be targeted by altering molecular mechanisms.This article is categorized under:RNA in Disease and Development > RNA in DiseaseRNA Interactions with Proteins and Other Molecules > Protein-RNA Inter-actions: Functional ImplicationsRNA Processing > RNA Editing and Modificationen_US
dc.identifier.citationÇayır, A. (2021). RNA modifications as emerging therapeutic targets. Wiley Interdisciplinary Reviews: RNA, 13(4). https://doi.org/10.1002/wrna.1702en_US
dc.identifier.doi10.1002/wrna.1702
dc.identifier.issn1757-7004
dc.identifier.issn1757-7012
dc.identifier.issue4en_US
dc.identifier.pmid34816607
dc.identifier.scopus2-s2.0-85119661084
dc.identifier.urihttps://doi.org/10.1002/wrna.1702
dc.identifier.urihttps://hdl.handle.net/20.500.12428/6733
dc.identifier.volume13en_US
dc.identifier.wosWOS:000721773000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇayır, Akın
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofWiley Interdisciplinary Reviews: RNAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug discoveryen_US
dc.subjectm6Aen_US
dc.subjectRNA modificationsen_US
dc.subjectRNA modifying genesen_US
dc.titleRNA modifications as emerging therapeutic targets
dc.typeReview Article

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