An evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study

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dc.authoridArikan, Ali Ahmet/0000-0002-9599-1577
dc.contributor.authorOzbudak, Ersan
dc.contributor.authorEraldemir, Fatma Ceyla
dc.contributor.authorArikan, Ali Ahmet
dc.contributor.authorSahin, Deniz
dc.contributor.authorKir, Hale Maral
dc.contributor.authorKurt, Tolga
dc.contributor.authorGulasti, Omer Faruk
dc.date.accessioned2025-01-27T20:47:32Z
dc.date.available2025-01-27T20:47:32Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: This study aims to compare clopidogrel and rivaroxaban against ischemia-reperfusion injury after a long reperfusion time and to investigate its effects on various tissues. Methods: A total of 40 Wistar rats were included in the study and were randomly divided into four groups (n=10 per group). Groups were defined as follows: control (Group 1), sham (Group 2), clopidogrel pre-treatment (Group 3), and rivaroxaban pre-treatment (Group 4). Ischemia (6 h) and reperfusion (8 h) were induced at the lower hind limb in Groups 2, 3, and 4. The ischemic muscle, heart, kidney, liver, and plasma tissues of the subjects were obtained to test for the oxidant (malondialdehyde) and antioxidants (glutathione, superoxide dismutase, and nitric oxide). Results: Malondialdehyde levels were significantly higher in the sham group, compared to the controls in all tissues. Clopidogrel and rivaroxaban pre-treatment significantly decreased malondialdehyde levels, compared to the heart, ischemic muscle, liver, and blood tissues of the sham group. Kidney malondialdehyde levels were reduced only by rivaroxaban. Group 4 had significantly decreased malondialdehyde levels, compared to Group 3 in ischemic muscle (p<0.010). The glutathione reduction, compared to sham group, in the kidney was only significant for Group 4 (p<0.050). With clopidogrel and rivaroxaban pretreatment, nitric oxide levels significantly decreased only in the heart tissue, compared to sham group (p<0.001 and p<0.050, respectively). Conclusion: The study results suggest that rivaroxaban and clopidogrel are effective in reducing ischemia-reperfusion injury in the heart, ischemic muscle, liver, and blood. Rivaroxaban also protects the kidneys and is superior to clopidogrel in ischemic muscle protection.
dc.identifier.doi10.5606/tgkdc.dergisi.2019.18061
dc.identifier.endpage520
dc.identifier.issn1301-5680
dc.identifier.issue4
dc.identifier.pmid32082919
dc.identifier.scopus2-s2.0-85074357264
dc.identifier.scopusqualityQ3
dc.identifier.startpage513
dc.identifier.trdizinid339329
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2019.18061
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/339329
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24947
dc.identifier.volume27
dc.identifier.wosWOS:000492824600016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAnimal experiment
dc.subjectclopidogrel
dc.subjectischemia
dc.subjectreperfusion injury
dc.subjectrivaroxaban
dc.titleAn evaluation of rivaroxaban and clopidogrel in a rat lower extremity ischemia-reperfusion model: An experimental study
dc.typeArticle

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