Vitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study

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dc.authoridOcak, Ozgul/0000-0001-8276-0174
dc.contributor.authorCakina, Suat
dc.contributor.authorOcak, Ozgul
dc.contributor.authorOzkan, Adile
dc.contributor.authorYucel, Selma
dc.contributor.authorKaraman, Handan Isin Ozisik
dc.date.accessioned2025-01-27T20:44:20Z
dc.date.available2025-01-27T20:44:20Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMultiple sclerosis (MS) is a common neurologic disorder that is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Its etiology remains unknown. Several recent studies have found that decreased susceptibility to vitamin D deficiency is also associated with a decreased risk of MS. The role of vitamin D receptor (VDR) gene and its polymorphisms are highlighted as susceptible components. In this study, we aimed to identify the relationship between Apal (rs7975232), BsmI (rs 1544410), and TaqI (rs731236) gene polymorphisms with MS. Apal, Bsml, and TaqI genotypes were determined in 70 patients with MS and in 70 control subjects. DNA was isolated from blood samples, and then Apal, BsmI and TaqI gene polymorphisms were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The distribution of BsmI and TaqI polymorphisms did not show any significant differences in MS patients and controls; however, increased A allele of Apal polymorphism was found in MS patients. Our findings suggest that the Apal gene polymorphism might be associated with MS. Investigation of a larger population and functional work on these gene structures and function in MS patients are recommended.
dc.identifier.doi10.2478/rrlm-2018-0028
dc.identifier.endpage495
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85055323292
dc.identifier.scopusqualityN/A
dc.identifier.startpage489
dc.identifier.urihttps://doi.org/10.2478/rrlm-2018-0028
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24543
dc.identifier.volume26
dc.identifier.wosWOS:000448823500010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Press
dc.relation.ispartofRevista Romana De Medicina De Laborator
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectmultiple sclerosis
dc.subjectvitamin D
dc.subjectvitamin D receptor (VDR) gene polymorphism
dc.titleVitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study
dc.typeArticle

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