Vitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study
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Tarih
2018
Yazarlar
Cakina, Suat
Ocak, Ozgul
Ozkan, Adile
Yucel, Selma
Karaman, Handan Isin Ozisik
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Multiple sclerosis (MS) is a common neurologic disorder that is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Its etiology remains unknown. Several recent studies have found that decreased susceptibility to vitamin D deficiency is also associated with a decreased risk of MS. The role of vitamin D receptor (VDR) gene and its polymorphisms are highlighted as susceptible components. In this study, we aimed to identify the relationship between Apal (rs7975232), BsmI (rs 1544410), and TaqI (rs731236) gene polymorphisms with MS. Apal, Bsml, and TaqI genotypes were determined in 70 patients with MS and in 70 control subjects. DNA was isolated from blood samples, and then Apal, BsmI and TaqI gene polymorphisms were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The distribution of BsmI and TaqI polymorphisms did not show any significant differences in MS patients and controls; however, increased A allele of Apal polymorphism was found in MS patients. Our findings suggest that the Apal gene polymorphism might be associated with MS. Investigation of a larger population and functional work on these gene structures and function in MS patients are recommended.
Açıklama
Anahtar Kelimeler
multiple sclerosis, vitamin D, vitamin D receptor (VDR) gene polymorphism
Kaynak
Revista Romana De Medicina De Laborator
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
26
Sayı
4
