Studying protein-protein interactions: Latest and most popular approaches

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dc.contributor.authorAkbarzadeh, Sama
dc.contributor.authorCoskun, Ozlem
dc.contributor.authorGuncer, Basak
dc.date.accessioned2025-01-27T20:54:24Z
dc.date.available2025-01-27T20:54:24Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPPIs, or protein-protein interactions, are essential for many biological processes. According to the findings, abnormal PPIs have been linked to several diseases, such as cancer and infectious and neurological disorders. Consequently, focusing on PPIs is a path toward disease treatment and a crucial tool for producing novel medications. Many methods exist to investigate PPIs, including low- and high-throughput studies. Since many PPIs have been discovered using in vitro and in vivo experimental approaches, the use of computational methods to predict PPIs has grown due to the expanding scale of PPI data and the intrinsic complexity of interacting mechanisms. Recognizing PPI networks offers a systematic means of predicting protein functions, and pathways that are included. These investigations can help uncover the underlying molecular mechanisms of complex phenotypes and clarify the biological processes related to health and diseases. Therefore, our goal in this study is to provide an overview of the latest and most popular approaches for investigating PPIs. We also overview some important clinical approaches based on the PPIs and how these interactions can be targeted.
dc.identifier.doi10.1016/j.jsb.2024.108118
dc.identifier.issn1047-8477
dc.identifier.issn1095-8657
dc.identifier.issue4
dc.identifier.pmid39214321
dc.identifier.scopus2-s2.0-85202974344
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jsb.2024.108118
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26064
dc.identifier.volume216
dc.identifier.wosWOS:001306818400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Structural Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectProtein-Protein Interaction (PPI) Networks
dc.subjectHigh-Throughput Screening (HTS)
dc.subjectComputational approaches
dc.subjectStructural bioinformatics
dc.subjectInteractome analysis
dc.titleStudying protein-protein interactions: Latest and most popular approaches
dc.typeReview Article

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