The effects of Macrovipera lebetina venom on mice

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dc.authoridAGAN, AYDAN FULDEN/0000-0002-4319-6264
dc.authoridHAYRETDAG, SIBEL/0000-0001-6380-4725
dc.contributor.authorAgan, Aydan Fulden Yucel
dc.contributor.authorHayretdag, Sibel
dc.date.accessioned2025-01-27T20:58:24Z
dc.date.available2025-01-27T20:58:24Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study is to reveal the effects Macrovipera lebetina venom - one of the two most venomous (the other one is Montivipera xanthina) snake species in Turkey - histopathologically on liver, kidney and heart tissues of mice. The venom was injected into the tail veins of male mice at three different doses (0.5, 1 and 1.5 mg kg(-1)). The animals were dissected 2 h after the injection, and their liver, kidney and heart tissues were examined histologically by light microscopy. Results of histopathological examination showed, degeneration, mononuclear cell infiltration, vacuoles around the nuclei and sinuzoidal congestion in livers; cellular degeneration, deformation in the structure of the glomerulus, intertubular congestion and mononuclear cell infiltration in the kidneys; and vacuoles around the nucleus, necrosis, congestion and mononuclear cell infiltration in heart tissues.
dc.description.sponsorshipScientific Research Project Commission at Canakkale Onsekiz Mart University [2012/052]
dc.description.sponsorshipThis study was supported by the Scientific Research Project Commission (2012/052) at Canakkale Onsekiz Mart University.
dc.identifier.doi10.1080/15569543.2017.1419266
dc.identifier.endpage92
dc.identifier.issn1556-9543
dc.identifier.issn1556-9551
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85039545348
dc.identifier.scopusqualityQ1
dc.identifier.startpage87
dc.identifier.urihttps://doi.org/10.1080/15569543.2017.1419266
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26694
dc.identifier.volume38
dc.identifier.wosWOS:000467399100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofToxin Reviews
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHistopathology
dc.subjectViperidae
dc.subjectvenom
dc.subjectkidney
dc.subjectliver and heart muscle
dc.titleThe effects of Macrovipera lebetina venom on mice
dc.typeArticle

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