The effects of Macrovipera lebetina venom on mice
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Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study is to reveal the effects Macrovipera lebetina venom - one of the two most venomous (the other one is Montivipera xanthina) snake species in Turkey - histopathologically on liver, kidney and heart tissues of mice. The venom was injected into the tail veins of male mice at three different doses (0.5, 1 and 1.5 mg kg(-1)). The animals were dissected 2 h after the injection, and their liver, kidney and heart tissues were examined histologically by light microscopy. Results of histopathological examination showed, degeneration, mononuclear cell infiltration, vacuoles around the nuclei and sinuzoidal congestion in livers; cellular degeneration, deformation in the structure of the glomerulus, intertubular congestion and mononuclear cell infiltration in the kidneys; and vacuoles around the nucleus, necrosis, congestion and mononuclear cell infiltration in heart tissues.
Açıklama
Anahtar Kelimeler
Histopathology, Viperidae, venom, kidney, liver and heart muscle
Kaynak
Toxin Reviews
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
38
Sayı
2
