Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAkman, Tarik
dc.contributor.authorOzkan, Adile
dc.contributor.authorSen, Halil Murat
dc.contributor.authorDuz, Ugur
dc.contributor.authorKalkan, Yildiray
dc.date.accessioned2025-01-27T20:43:34Z
dc.date.available2025-01-27T20:43:34Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDaidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis.
dc.identifier.doi10.4103/1673-5374.150724
dc.identifier.endpage152
dc.identifier.issn1673-5374
dc.identifier.issue1
dc.identifier.pmid25788936
dc.identifier.scopus2-s2.0-84923044535
dc.identifier.scopusqualityQ1
dc.identifier.startpage146
dc.identifier.urihttps://doi.org/10.4103/1673-5374.150724
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24270
dc.identifier.volume10
dc.identifier.wosWOS:000350098100033
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherShenyang Editorial Dept Neural Regeneration Res
dc.relation.ispartofNeural Regeneration Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectnerve regeneration
dc.subjectbrain ischemia
dc.subjectstroke
dc.subjectdaidzein
dc.subjectoxidative stress
dc.subjectapoptosis
dc.subjectsuperoxide dismutase
dc.subjectmalondialdehyde
dc.subjectnuclear respiratory factor 1
dc.subjectneural regeneration
dc.titleNeuroprotective effects of daidzein on focal cerebral ischemia injury in rats
dc.typeArticle

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