Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Shenyang Editorial Dept Neural Regeneration Res
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis.
Açıklama
Anahtar Kelimeler
nerve regeneration, brain ischemia, stroke, daidzein, oxidative stress, apoptosis, superoxide dismutase, malondialdehyde, nuclear respiratory factor 1, neural regeneration
Kaynak
Neural Regeneration Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
10
Sayı
1
