Super-Macroporous Pulluan Cryogels as Controlled Active Delivery Systems with Controlled Degradability

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dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridAri, Betül / 0000-0003-3557-3055
dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorAri, Betül
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:26:57Z
dc.date.available2025-01-27T20:26:57Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
dc.description.abstractHere, super-macroporous cryogel from a natural polysaccharide, pullulan was synthesized using a cryo-crosslinking technique with divinyl sulfone (DVS) as a crosslinker. The hydrolytic degradation of the pullulan cryogel in various simulated body fluids (pH 1.0, 7.4, and 9.0 buffer solutions) was evaluated. It was observed that the pullulan cryogel degradation was much faster in the pH 9 buffer solution than the pH 1.0 and 7.4 buffer solutions in the same time period. The weight loss of the pullulan cryogel at pH 9.0 within 28 days was determined as 31% & PLUSMN; 2%. To demonstrate the controllable drug delivery potential of pullulan cryogels via degradation, an antibiotic, ciprofloxacin, was loaded into pullulan cryogels (pullulan-cipro), and the loading amount of drug was calculated as 105.40 & PLUSMN; 2.6 & mu;g/mg. The release of ciprofloxacin from the pullulan-cipro cryogel was investigated in vitro at 37.5 & DEG;C in physiological conditions (pH 7.4). The amount of drug released within 24 h was determined as 39.26 & PLUSMN; 3.78 & mu;g/mg, which is equal to 41.38% & PLUSMN; 3.58% of the loaded drug. Only 0.1 mg of pullulan-cipro cryogel was found to inhibit half of the growing Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) colonies for 10 min and totally eradicated within 2 h by the release of the loaded antibiotic. No significant toxicity was determined on L929 fibroblast cells for 0.1 mg drug-loaded pullulan cryogel. In contrast, even 1 mg of drug-loaded pullulan cryogel revealed slight toxicity (e.g., 66% & PLUSMN; 9% cell viability) because of the high concentration of released drug.
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University [FBA-2022-3904]; Canakkale Onsekiz Mart University Scientific Research Commission
dc.description.sponsorshipThis work was funded by the Scientific Research Commission of Canakkale Onsekiz Mart University (project number: FBA-2022-3904).
dc.identifier.doi10.3390/mi14071323
dc.identifier.issn2072-666X
dc.identifier.issue7
dc.identifier.pmid37512634
dc.identifier.scopus2-s2.0-85166209942
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/mi14071323
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22516
dc.identifier.volume14
dc.identifier.wosWOS:001036458800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMicromachines
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectbiocompatible
dc.subjectdegradable polysaccharide cryogel
dc.subjectpullulan cryogel
dc.subjectnatural polymeric cryogel drug carrier
dc.subjectciprofloxacin release
dc.titleSuper-Macroporous Pulluan Cryogels as Controlled Active Delivery Systems with Controlled Degradability
dc.typeArticle

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