Human-Derived Fibrin Glue: In Vitro Antibacterial Effects and Antibiotic Permeation

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dc.contributor.authorYuksel, Erdem
dc.contributor.authorAkata, Fikret
dc.contributor.authorYuksel, Nilay
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorMert, Bedia Dinc
dc.date.accessioned2025-01-27T21:20:03Z
dc.date.available2025-01-27T21:20:03Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study investigated the in vitro antibacterial efficacy and antibiotic permeation of human-derived fibrin glue (FG). Materials and Methods: FG was prepared under sterile conditions by the Blood Bank of Gazi University Faculty of Medicine. In this study, cultivations were performed in 5 main groups: Group 1 (control) - only FG; Group 2a (control) - pure Staphylococcus aureus (SA) and Group 2b (control) - pure Staphylococcus epidermidis (SE); Group 3a (control) - SA+ antibiotic and Group 3b ( control) SE+ antibiotic; Group 4a - FG+SA and Group 4b - FG+SE; Group 5a - FG+SA+ antibiotic and Group 5b - FG+SA+ antibiotic. Results: Group 1 showed no bacterial growth, whereas Group 2a and Group 2b, Group 4a and Group 4b showed bacterial growth. Group 5a and Group 5b showed no growth. Conclusion: Although FG has no antibacterial efficacy in vitro, it may be used safely due to antibiotic permeation in diseases with either infected or non-infected ocular surface that require suturing.
dc.identifier.doi10.4274/tjo.60024
dc.identifier.endpage350
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84908206435
dc.identifier.scopusqualityN/A
dc.identifier.startpage347
dc.identifier.trdizinid163945
dc.identifier.urihttps://doi.org/10.4274/tjo.60024
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/163945
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28805
dc.identifier.volume44
dc.identifier.wosWOS:000219230800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Ophthalmological Soc
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAntibacterial activity
dc.subjectcorneal perforation
dc.subjectfibrin glue
dc.subjectsutureless amniotic membrane transplantation
dc.titleHuman-Derived Fibrin Glue: In Vitro Antibacterial Effects and Antibiotic Permeation
dc.title.alternativeİnsan kaynaklı doku yapıştırıcısı: İn vitro antibakteriyel etkinliği ve antibiyotik geçirgenliği
dc.typeArticle

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