Phage-encoded carbohydrate-interacting proteins in the human gut

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dc.authorid-en_US
dc.authorid0000-0003-4056-1673en_US
dc.authorscopusid57210425578en_US
dc.authorscopusid56688659000en_US
dc.authorwosid-en_US
dc.authorwosidT-8649-2018en_US
dc.contributor.authorRothschild-Rodriguez, Daniela
dc.contributor.authorHedges, Morgen
dc.contributor.authorKaplan, Merve
dc.contributor.authorKarav, Sercan
dc.contributor.authorNobrega, Franklin L.
dc.date.accessioned2024-01-25T07:47:37Z
dc.date.available2024-01-25T07:47:37Z
dc.date.issued2023en_US
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractIn the human gastrointestinal tract, the gut mucosa and the bacterial component of the microbiota interact and modulate each other to accomplish a variety of critical functions. These include digestion aid, maintenance of the mucosal barrier, immune regulation, and production of vitamins, hormones, and other metabolites that are important for our health. The mucus lining of the gut is primarily composed of mucins, large glycosylated proteins with glycosylation patterns that vary depending on factors including location in the digestive tract and the local microbial population. Many gut bacteria have evolved to reside within the mucus layer and thus encode mucus-adhering and -degrading proteins. By doing so, they can influence the integrity of the mucus barrier and therefore promote either health maintenance or the onset and progression of some diseases. The viral members of the gut – mostly composed of bacteriophages – have also been shown to have mucus-interacting capabilities, but their mechanisms and effects remain largely unexplored. In this review, we discuss the role of bacteriophages in influencing mucosal integrity, indirectly via interactions with other members of the gut microbiota, or directly with the gut mucus via phage-encoded carbohydrate-interacting proteins. We additionally discuss how these phage-mucus interactions may influence health and disease states.en_US
dc.identifier.citationRothschild-Rodriguez, D., Hedges, M., Kaplan, M., Karav, S., & Nobrega, F. L. (2023). Phage-encoded carbohydrate-interacting proteins in the human gut. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.1083208en_US
dc.identifier.doi10.3389/fmicb.2022.1083208
dc.identifier.issn1664-302X
dc.identifier.pmid36687636
dc.identifier.scopus2-s2.0-85146524895
dc.identifier.urihttps://doi.org/10.3389/fmicb.2022.1083208
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5426
dc.identifier.volume13en_US
dc.identifier.wosWOS:000914011600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, Merve
dc.institutionauthorKarav, Sercan
dc.language.isoen
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Microbiologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBacteriophageen_US
dc.subjectGlycansen_US
dc.subjectGlycosylationen_US
dc.subjectGuten_US
dc.subjectMucinsen_US
dc.subjectMucusen_US
dc.subjectMucus-bindingen_US
dc.subjectMucus-degradingen_US
dc.titlePhage-encoded carbohydrate-interacting proteins in the human gut
dc.typeReview Article

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