Heterogeneous and homogeneous structure dextran-poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study

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dc.contributor.authorEkici, Sema
dc.date.accessioned2025-01-27T20:51:51Z
dc.date.available2025-01-27T20:51:51Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractpH-sensitive dextran-poly(methacrylic acid) (Dext-pMeAc) full interpenetrating network hydrogels (INHs) were prepared by simultaneous radical polymerization of methacrylic acid monomer (MeAc) and Dext polymer chains in the presence of N,N-methylenebisacrylamide (MBA) as crosslinker in aqueous solution. These hydrogels were investigated as a drug carrier. The influence of MeAc and MBA contents in the network hydrogels on the swelling behaviour and mechanical strength of prepared Dext-pMeAc INHs was evaluated. Dext-pMeAc INHs were characterized by Fourier transform IR spectroscopy, and kinetic swelling measurements were carried out in deionized water and in simulated gastric fluids (pH 1.1 and pH 7.4). Dext-pMeAc/1-1, Dext-pMeAc/3-1 and Dext-pMeAc/5-1 hydrogels with molar ratios of n(Dext)/n(MeAc) = 10 and n(MBA)/n(Dext) = 10, 30 and 50 respectively showed a core-shell structure when they swelled. This phenomenon was not observed in Dext-pMeAc/5-2, Dext-pMeAc/5-3 and Dext-pMeAc/5-5 hydrogels containing a higher amount of Dext in the gels. The swelling data proved the formation of INHs with pH-sensitive behaviour. A drug release study was performed using Rhodamine 6G fluorescent dye as a model hydrophilic bioactive molecule. The in vitro release rate of Rhodamine 6G from Dext-pMeAc/5-3 hydrogel was dependent on the pH of the release medium. (C) 2012 Society of Chemical Industry
dc.description.sponsorshipCanakkale Onsekiz Mart University Research Fund (BAP) [2009/163]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University Research Fund (BAP), under Project No. 2009/163.
dc.identifier.doi10.1002/pi.4267
dc.identifier.endpage1766
dc.identifier.issn0959-8103
dc.identifier.issn1097-0126
dc.identifier.issue12
dc.identifier.scopus2-s2.0-84873480291
dc.identifier.scopusqualityQ1
dc.identifier.startpage1758
dc.identifier.urihttps://doi.org/10.1002/pi.4267
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25542
dc.identifier.volume61
dc.identifier.wosWOS:000313900700009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymer International
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectdextran
dc.subjectbiopolymer
dc.subjectpoly(methacrylic acid)
dc.subjectinterpenetrating network hydrogel
dc.subjectdrug release
dc.subjectRhodamine 6G
dc.titleHeterogeneous and homogeneous structure dextran-poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study
dc.typeArticle

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