Heterogeneous and homogeneous structure dextran-poly(methacrylic acid) interpenetrating network hydrogels: synthesis and an application study
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Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
pH-sensitive dextran-poly(methacrylic acid) (Dext-pMeAc) full interpenetrating network hydrogels (INHs) were prepared by simultaneous radical polymerization of methacrylic acid monomer (MeAc) and Dext polymer chains in the presence of N,N-methylenebisacrylamide (MBA) as crosslinker in aqueous solution. These hydrogels were investigated as a drug carrier. The influence of MeAc and MBA contents in the network hydrogels on the swelling behaviour and mechanical strength of prepared Dext-pMeAc INHs was evaluated. Dext-pMeAc INHs were characterized by Fourier transform IR spectroscopy, and kinetic swelling measurements were carried out in deionized water and in simulated gastric fluids (pH 1.1 and pH 7.4). Dext-pMeAc/1-1, Dext-pMeAc/3-1 and Dext-pMeAc/5-1 hydrogels with molar ratios of n(Dext)/n(MeAc) = 10 and n(MBA)/n(Dext) = 10, 30 and 50 respectively showed a core-shell structure when they swelled. This phenomenon was not observed in Dext-pMeAc/5-2, Dext-pMeAc/5-3 and Dext-pMeAc/5-5 hydrogels containing a higher amount of Dext in the gels. The swelling data proved the formation of INHs with pH-sensitive behaviour. A drug release study was performed using Rhodamine 6G fluorescent dye as a model hydrophilic bioactive molecule. The in vitro release rate of Rhodamine 6G from Dext-pMeAc/5-3 hydrogel was dependent on the pH of the release medium. (C) 2012 Society of Chemical Industry
Açıklama
Anahtar Kelimeler
dextran, biopolymer, poly(methacrylic acid), interpenetrating network hydrogel, drug release, Rhodamine 6G
Kaynak
Polymer International
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
61
Sayı
12
