Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorGholamalizadeh, Hanieh
dc.contributor.authorEnsan, Behzad
dc.contributor.authorKarav, Sercan
dc.contributor.authorJamialahmadi, Tannaz
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2025-01-27T20:45:46Z
dc.date.available2025-01-27T20:45:46Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackgroundHMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CCL2/CCR2 axis.MethodScopus and Pubmed databases were systematically searched using the following keywords: Hydroxymethylglutaryl CoA Reductase Inhibitors, HMG-CoA Reductase Inhibitors, Statins, CCL2, Chemokine, Monocyte Chemoattractant Protein-1 and Chemokine (C-C Motif) Ligand 2. Evidence investigating the role of statin on MCP-1 in CVD was identified and bibliographies were completely evaluated to gather further related studies.ResultsThe anti-inflammatory effects of statins on the CCL2/CCR2 pathway have been widely investigated. Despite inconclusive results, a great body of research supports the regulatory roles of statins on this pathway due to their pleiotropic effects. By disrupting the CCL2/CCR2 axis, statins attenuate the infiltration of monocytes and macrophages into the zone of inflammation and hence down-regulate the inflammatory cascades in various CVDs including atherosclerosis, cardiac remodeling, and stroke, among others.ConclusionCCL2 plays a major role in the pathogenesis of cardiovascular disorders. Down-regulation of CCL2 is proposed as one of the pleiotropic properties of statins. However, more investigations are required to elucidate which statin in what dose exerts a more potent effect on CCL2/CCR2 pathway.
dc.identifier.doi10.1186/s12950-024-00420-y
dc.identifier.issn1476-9255
dc.identifier.issue1
dc.identifier.pmid39696507
dc.identifier.scopus2-s2.0-85212397986
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12950-024-00420-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24714
dc.identifier.volume21
dc.identifier.wosWOS:001379753900002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJournal of Inflammation-London
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectMCP-1
dc.subjectCCL2
dc.subjectStatins
dc.subjectIschemic heart disease
dc.subjectStroke
dc.titleRegulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins
dc.typeArticle

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