Lactoperoxidase: Properties, Functions, and Potential Applications

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dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.authoridDuman, Hatice / 0000-0002-4526-6609
dc.contributor.authorÖzhan, Hasan Kutluay
dc.contributor.authorDuman, Hatice
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T11:59:59Z
dc.date.available2026-02-03T11:59:59Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLactoperoxidase (LPO) (E.C. 1.11.1.7) is a member of the superfamily of mammalian heme peroxidases that is isolated from milk, and it is the first enzyme announced to be found in milk. In addition to milk, LPO is also found in saliva, tears, and airways (airway goblet cells and submucosal glands). It contributes significantly to the self-defense of the mammal body. It catalyzes the oxidation of certain molecules such as thiocyanate (SCN-), I-, and Br- in the presence of hydrogen peroxide (H2O2). This reaction leads to the formation of antimicrobial products that have a great antimicrobial spectrum, including antibacterial, antiviral, and antifungal activity, especially hypothiocyanite (OSCN-) and hypoiodite (OI-), which are coming into prominence via their high antimicrobial activity. The lactoperoxidase system (LPOS) is the system consisting of LPO, H2O2, and SCN-. LPO has a great potential to be used in various areas such as preservation and shelf-life elongation of milk; milk products; meat; meat products; plants, including fruits and vegetables; and oral care, diagnosis, immunomodulation, and treatment of nephrotoxicity. The LPO gene, along with LPO itself, is important for animals. In the absence of the LPO gene, there is an increase in the frequency of diverse diseases, including inflammation, tumor formation, and obesity. In this review, we mentioned general information about the enzyme LPO and its potential. Chemical properties and other features of other components of the LPOS, H2O2, and SCN- were also touched on the review. To offer readers a comprehensive understanding of the enzyme's biological significance and research progress over time, both recent and older studies have been used together. Lastly, we discussed potential applications of LPO in different areas and left future remarks in the light of recent studies.
dc.identifier.doi10.3390/ijms26115055
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue11
dc.identifier.pmid40507866
dc.identifier.scopus2-s2.0-105007802890
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms26115055
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34464
dc.identifier.volume26
dc.identifier.wosWOS:001505995900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectlactoperoxidase
dc.subjectmilk
dc.subjectantibacterial
dc.subjectantiviral
dc.subjectantifungal
dc.subjectenzyme
dc.subjectoxidation
dc.subjecttherapeutic
dc.titleLactoperoxidase: Properties, Functions, and Potential Applications
dc.typeReview Article

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