A nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1/Park7 in cerebrospinal fluid and saliva

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dc.authorid0000-0003-3042-1087en_US
dc.authorscopusid6506764918en_US
dc.authorwosidAAY-1439-2021en_US
dc.contributor.authorSonuç Karaboğa, Münteha Nur
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2024-12-23T06:54:26Z
dc.date.available2024-12-23T06:54:26Z
dc.date.issued2021en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractIn this study, we developed an electrochemical-based single-use neurobiosensor based on multiwalled carbon nanotube (MWCNT)-gold nanoparticle (AuNP) nanocomposite doped, 11-amino-1-undecanethiol (11-AUT)-modified polyethylene terephthalate coated indium tin oxide (ITO-PET) electrodes. This electrode was used for the sensitive determination of DJ-1, a protein responsible for mitochondrial dysfunction in Parkinson's disease (PD) with the task of eliminating oxidative stress. The design strategy and analytical studies for the neurobiosensor were monitored with electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and single frequency impedance (SFI) techniques. The selective determination range for DJ-1 of the developed neurobiosensor system is 4.7–4700 fg mL−1 in accordance with the charge transfer resistance (Rct) associated with a limit of detection of 0.5 fg mL−1. Since changes in the expression of DJ-1 protein is particularly important in cerebrospinal fluid (CSF) and saliva, the ability of the developed neurobiosensor system to detect the DJ-1 protein in these media was tested by the standard addition method. The statistical results show that the biosensor decorated with MWCNT-AuNP-AUT may be recommended for the selective determination of DJ-1 protein.en_US
dc.identifier.citationSonuç Karaboğa, M. N., & Sezgintürk, M. K. (2021). A nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1/Park7 in cerebrospinal fluid and saliva. Bioelectrochemistry, 138, 107734. https://doi.org/10.1016/j.bioelechem.2020.107734en_US
dc.identifier.doi10.1016/j.bioelechem.2020.107734
dc.identifier.issn1567-5394
dc.identifier.issn1878-562X
dc.identifier.pmid33421895
dc.identifier.scopus2-s2.0-85099020205
dc.identifier.urihttps://doi.org/10.1016/j.bioelechem.2020.107734
dc.identifier.urihttps://hdl.handle.net/20.500.12428/6772
dc.identifier.volume138en_US
dc.identifier.wosWOS:000656695600007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherElsevier B.V.en_US
dc.relation.ispartofBioelectrochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiosensoren_US
dc.subjectDJ-1en_US
dc.subjectMWCNTen_US
dc.subjectNeurodegenerationen_US
dc.subjectParkinson's diseaseen_US
dc.titleA nano-composite based regenerative neuro biosensor sensitive to Parkinsonism-associated protein DJ-1/Park7 in cerebrospinal fluid and saliva
dc.typeArticle

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