Biocompatible Glycol Chitosan Microgels as Effective Drug Carriers

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dc.authorid0000-0001-8666-7954en_US
dc.authorid0000-0002-5260-7678en_US
dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid24472372400en_US
dc.authorscopusid57928942000en_US
dc.authorscopusid6602001525en_US
dc.authorwosidAAB-6714-2020en_US
dc.authorwosid-en_US
dc.authorwosidDVD-0927-2022en_US
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorYılmaz, Aynur Sanem
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2024-01-16T06:54:50Z
dc.date.available2024-01-16T06:54:50Z
dc.date.issued2023en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.departmentRektörlük, Rektörlüğe Bağlı Bölümler, Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi
dc.description.abstractGlycol chitosan (GC) is a chitosan (CH) derivative with improved water solubility with regards to CH which affords significant solubility advantages. In this study, microgels of GC as p(GC) were synthesized by a microemulsion technique at various crosslinking ratios e.g., 5%, 10%, 50%, 75%, and 150% based on the repeating unit of GC using divinyl sulfone (DVS) as a crosslinker. The prepared p(GC) microgels were tested for blood compatibility and it was found that p(GC) microgels at 1.0 mg/mL concentration possessed a 1.15 ± 0.1% hemolysis ratio and 89 ± 5% blood clotting index value confirming their hemocompatibility. In addition, p(GC) microgels were found biocompatible with 75.5 ± 5% cell viability against L929 fibroblasts even at a 2.0 mg/mL concentration. By loading and releasing tannic acid (TA) (a polyphenolic compound with high antioxidant activity) as an active agent, p(GC) microgels’ possible drug delivery device application was examined. The TA loading amount of p(GC) microgels was determined as 323.89 mg/g, and TA releases from TA loaded microgels (TA@p(GC)) were found to be linear within 9 h and a total amount of TA released was determined as 42.56 ± 2 mg/g within 57 h. According to the Trolox equivalent antioxidant capacity (TEAC) test, 400 µL of the sample added to the ABTS+ solution inhibited 68.5 ± 1.7% of the radicals. On the other hand, the total phenol content (FC) test revealed that 2000 μg/mL of TA@p(GC) microgels resulted in 27.5 ± 9.5 mg/mL GA eq antioxidant properties.en_US
dc.identifier.citationŞahiner, M., Yilmaz, A. S., Ayyala, R. S., & Şahiner, N. (2023). Biocompatible Glycol Chitosan Microgels as Effective Drug Carriers. Gels, 9(5). https://doi.org/10.3390/gels9050398en_US
dc.identifier.doi10.3390/gels9050398
dc.identifier.issn2310-2861
dc.identifier.issue5en_US
dc.identifier.pmid37232990
dc.identifier.scopus2-s2.0-85160316455
dc.identifier.urihttps://doi.org/10.3390/gels9050398
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5252
dc.identifier.volume9en_US
dc.identifier.wosWOS:001020188600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorYılmaz, Aynur Sanem
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMDPIen_US
dc.relation.ispartofGelsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAntioxidant activityen_US
dc.subjectDrug delivery systemen_US
dc.subjectGlycol chitosan microsphereen_US
dc.subjectNatural polymeric drug carriersen_US
dc.subjectTannic aciden_US
dc.titleBiocompatible Glycol Chitosan Microgels as Effective Drug Carriers
dc.typeArticle

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