Chondroitin Sulfate-Based Cryogels for Biomedical Applications

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dc.authoridDemirci, Şahin / 0000-0001-7083-1481en_US
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954en_US
dc.authoridAri, Betül / 0000-0003-3557-3055en_US
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530Xen_US
dc.authorscopusidDemirci, Şahin / 56026625600en_US
dc.authorscopusidŞahiner, Mehtap / 24472372400en_US
dc.authorscopusidAri, Betül / 57392706000en_US
dc.authorscopusidŞahiner, Nurettin / 6602001525en_US
dc.authorwosidDemirci, Şahin / HQZ-4087-2023en_US
dc.authorwosidŞahiner, Mehtap / AAB-6714-2020en_US
dc.authorwosidŞahiner, Nurettin / DVD-0927-2022en_US
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorAri, Betül
dc.contributor.authorSunol, Aydın K.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2023-07-11T05:54:57Z
dc.date.available2023-07-11T05:54:57Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentRektörlük, Rektörlüğe Bağlı Bölümler, Nanobilim ve Teknoloji Araştırma ve Uygulama Merkezi
dc.departmentÇanakkale Uygulamalı Bilimler Yüksekokulu, Moda Tararım Bölümü
dc.description.abstractCryogels attained from natural materials offer exceptional properties in applications such as tissue engineering. Moreover, Halloysite Nanotubes (HNT) at 1:0.5 weight ratio were embedded into CS cryogels to render additional biomedical properties. The hemolysis index of CS cryogel and CS:HNT cryogels was calculated as 0.77 ± 0.41 and 0.81 ± 0.24 and defined as non-hemolytic mate-rials. However, the blood coagulation indices of CS cryogel and CS:HNT cryogels were determined as 76 ± 2% and 68 ± 3%, suggesting a mild blood clotting capability. The maximum% swelling capacity of CS cryogel was measured as 3587 ± 186%, 4014 ± 184%, and 3984 ± 113%, at pH 1.0, pH 7.4 and pH 9.0, respectively, which were reduced to 1961 ± 288%, 2816 ± 192, 2405 ± 73%, respectively, for CS:HNT cryogel. It was found that CS cryogels can hydrolytically be degraded 41 ± 1% (by wt) in 16-day incubation, whereas the CS:HNT cryogels degraded by 30 ± 1 wt %. There is no chelation for HNT and 67.5 ± 1% Cu(II) chelation for linear CS was measured. On the other hand, the CS cryogel and CS:HNT cryogel revealed Cu(II) chelating capabilities of 60.1 ± 12.5%, and 43.2 ± 17.5%, respectively, from 0.1 mg/mL Cu(II) ion stock solution. Additionally, at 0.5 mg/mL CS, CS:HNT, and HNT, the Fe(II) chelation capacity of 99.7 ± 0.6, 86.2 ± 4.7% and only 11.9 ± 4.5% were measured, respectively, while no Fe(II) was chelated by linear CS chelated Fe(II). As the adjustable and con-trollable swelling properties of cryogels are important parameters in biomedical applications, the swelling properties of CS cryogels, at different solution pHs, e.g., at the solution pHs of 1.0, 7.4 and 9.0, were measured as 3587 ± 186%, 4014 ± 184%, and 3984 ± 113%, respectively, and the maximum selling% values of CS:HNT cryogels were determined as 1961 ± 288%, 2816 ± 192, 2405 ± 73%, re-spectively, at the same conditions. Alpha glucosidase enzyme interactions were investigated and found that CS-based cryogels can stimulate this enzyme at any CS formulation.en_US
dc.identifier.citationDemirci, Ş., Şahiner, M., Ari, B., Sunol, A. K., & Şahiner, N. (2021). Chondroitin sulfate-based cryogels for biomedical applications. Gels, 7(3) doi:10.3390/gels7030127en_US
dc.identifier.doi10.3390/gels7030127
dc.identifier.issn2310-2861
dc.identifier.issue3en_US
dc.identifier.pmid34462411
dc.identifier.scopus2-s2.0-85114094345
dc.identifier.urihttps://doi.org/10.3390/gels7030127
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4342
dc.identifier.volume7en_US
dc.identifier.wosWOS:000700625300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemirci, Şahin
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorAri, Betül
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMDPIen_US
dc.relation.ispartofGelsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBlood compatibilityen_US
dc.subjectChondroitin sulfateen_US
dc.subjectCroyogelen_US
dc.subjectFibrinogen effecten_US
dc.subjectMetal chelatingen_US
dc.titleChondroitin Sulfate-Based Cryogels for Biomedical Applications
dc.typeArticle

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