Protective Effect of Ozone Against Gentamicin-Induced Neprotoxicity and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels: An Experimental Study

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dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.contributor.authorUstebay, Sefer
dc.contributor.authorUstebay, Dondu Ulker
dc.contributor.authorOzturk, Omur
dc.contributor.authorErtekin, Omer
dc.contributor.authorAdali, Yasemen
dc.date.accessioned2025-01-27T20:38:55Z
dc.date.available2025-01-27T20:38:55Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOur aim was to investigate the protective role of ozone treatment against gentamicin-induced nephrotoxicity in an experimental rat model. In this study, a total of 30 rats were allocated in 5 groups (n=6 in each group). The control group (Group 1) received isotonic saline only, while Groups 2 and 3 received gentamicin at doses of 15 mg/kg/day and 50 mg/kg/day, respectively. In Group 4, intraperitoneal ozone treatment (1 mg/kg, 5% O-3-95% O-2) was performed after administration of gentamicin at a dose of 15 mg/kg/day. Group 5 underwent ozone treatment intraperitoneally following the application of gentamicin (50 mg/kg/day). Nephrotoxicity was formed by administration of glycerol.Serum levels of urea, creatinine, neutrophil-gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), total antioxidant capacity (TAC) and protein carbonyl were measured, and kidneys were histopathologically examined after the sacrifice of animals on the 5th, day. Group 4 displayed more favorable outcomes regarding biochemical markers of oxidative stress such as NGAL, LDH, creatinine, urea, TAC and protein carbonyl. Similarly, histopathological alterations indicating gentamicin-induced nephrotoxicity such as hemorrhage, the presence of protein casts and epithelial injury in renal tubules were less evident in Groups 4 and 5 which received ozone treatment. To conclude, results of this experimental study demonstrated that ozone treatment might ameliorate biochemical disturbances and histopathological alterations linked with gentamicin-induced nephrotoxicity. However, furthertrials are warranted to document the actual therapeutic potential of ozone treatment in the clinical setting.
dc.identifier.doi10.9775/kvfd.2018.21097
dc.identifier.endpage404
dc.identifier.issn1300-6045
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85067454083
dc.identifier.scopusqualityQ3
dc.identifier.startpage397
dc.identifier.trdizinid337335
dc.identifier.urihttps://doi.org/10.9775/kvfd.2018.21097
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/337335
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23803
dc.identifier.volume25
dc.identifier.wosWOS:000460503100016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectGentamicin-induced nephrotoxicity
dc.subjectOzone
dc.subjectOxidative stress
dc.subjectNGAL
dc.subjectAntioxidant defense
dc.titleProtective Effect of Ozone Against Gentamicin-Induced Neprotoxicity and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels: An Experimental Study
dc.title.alternativeGentamisinin ındüklediği nefrotoksisitede ozonun koruyucu etkisi ve neutrophil gelatinase-associated lipocalin (NGAL) düzeyleri: Deneysel çalışma
dc.typeArticle

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