An innovative method for the detection of alpha synuclein, a potential biomarker of Parkinson's disease: quartz tuning fork-based mass sensitive immunosensor design

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dc.authorid0000-0003-3042-1087en_US
dc.authorscopusid6506764918en_US
dc.authorwosidAAY-1439-2021en_US
dc.contributor.authorSonuç Karaboğa, Münteha Nur
dc.contributor.authorÜnal, Mehmet Altay
dc.contributor.authorArı, Fikret
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2024-02-20T07:39:33Z
dc.date.available2024-02-20T07:39:33Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractAn innovative biosensing fabrication strategy has been demonstrated for the first time using a quartz tuning fork (QTF) to develop a practical immunosensor for sensitive, selective and practical analysis of alpha synuclein protein (SYN alpha), a potential biomarker of Parkinson's disease. Functionalization of gold-coated QTFs was carried out in 2 steps by forming a self-assembled monolayer with 4-aminothiophenol (4-ATP) and conjugation of gold nanoparticles (AuNPs). The selective determination range for SYN alpha of the developed biosensor system is 1–500 ng mL−1 in accordance with the resonance frequency shifts associated with a limit of detection of 0.098 ng mL−1. The changes in surface morphology and elemental composition were evaluated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and energy-dispersive X-ray spectroscopy (EDX). The remarkable point of the study is that this QTF based mass sensitive biosensor system can capture the SYN alpha target protein in cerebrospinal fluid (CSF) samples with recoveries ranging from 92% to 104%.en_US
dc.identifier.citationKaraboğa, M. N. S., Ünal, M. A., Arı, F., Sezgintürk, M. K., & Özkan, S. A. (2024). An innovative method for the detection of alpha synuclein, a potential biomarker of Parkinson’s disease: quartz tuning fork-based mass sensitive immunosensor design. Physical Chemistry Chemical Physics, 26(6), 5106–5114. https://doi.org/10.1039/D3CP04527Gen_US
dc.identifier.doi10.1039/D3CP04527G
dc.identifier.issn1463-9076
dc.identifier.issn1463-9084
dc.identifier.pmid38259152
dc.identifier.scopus2-s2.0-85183606244
dc.identifier.urihttps://doi.org/10.1039/D3CP04527G
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5661
dc.identifier.wosWOS:001146840900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofPhysical Chemistry Chemical Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunosensorsen_US
dc.subjectAlpha synucleinen_US
dc.subjectParkinson's diseaseen_US
dc.subjectBio-sensor systemsen_US
dc.subjectSynuclein proteinsen_US
dc.subjectSynucleinen_US
dc.titleAn innovative method for the detection of alpha synuclein, a potential biomarker of Parkinson's disease: quartz tuning fork-based mass sensitive immunosensor design
dc.typeArticle

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