Investigation of the Effects of Piceatannol on Endoplasmic Reticulum Stress on Brain in Rats with Experimental Subarachnoid Hemorrhage

Basit Öğe Kaydı
dc.contributor.authorOzbey, Berna
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:20:17Z
dc.date.available2025-01-27T20:20:17Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Subarachnoid hemorrhage (SAH) is a common neurologic disorder that accounts for brain injury, diminished neuron function, and neuronal death. Due to various options, SAH treatment remains lacking. Endoplasmic reticulum stress (ERS) in the brain is known as the disruption of the blood-brain barrier and triggered neuronal apoptosis, and contributes to SAH pathogenesis. This study aims to investigate the effects of piceatannol (PST) on ERS and neuronal apoptosis in an experimental SAH model in rats. Materials and Methods: For this purpose, 24 Wistar Albino male rats (8-10 w) were randomly divided into three groups (n=8); SHAM, SAH, and PST. SAH model was induced via injection of 120 mu L of autologous blood into pre-chiasmatic cisterna. 30 mg/kg PST was injected intraperitoneally after 60 minutes from SAH inducement. Garcia's neurologic examination, rotarod, and horizontal bar tests were applied for neurological evaluation. Frontal cortex specimens were harvested for histological and gene expression analysis. Results: Our results indicated that PST treatment significantly improved Garcia scores (p<0.01; p<0.05). In addition, PST decreased pyknosis (p<0.001) and edema (p<0.001) levels, and the number of damaged cells (p<0.01) and apoptotic cells (p<0.05). GRP78 (78-kDa glucose-regulated protein; p=0.01), ATF4 (Activating transcription factor 4; p=0.01), and CHOP (C/EBP homologous protein; p<0.05) gene expression levels of the SAH group were increased compared to SHAM. Moreover, PST significantly decreased the expression levels of p53 (p<0.01). Conclusion: Our results showed that PST indicated protective effects on ERS after SAH. It could be suggested that PST might be a supportive adjuvant agent in SAH management.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Unit [TYL-2021-3611]
dc.description.sponsorshipThis study was funded by Canakkale Onsekiz Mart University Scientific Research Projects Coordination Unit by TYL-2021-3611 numbered project.
dc.identifier.doi10.4274/nkmj.galenos.2024.02360
dc.identifier.endpage114
dc.identifier.issn2587-0262
dc.identifier.issue2
dc.identifier.startpage106
dc.identifier.trdizinid1282804
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2024.02360
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1282804
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21653
dc.identifier.volume12
dc.identifier.wosWOS:001266644800005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofNamik Kemal Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSubarachnoid hemorrhage
dc.subjectearly brain injury
dc.subjectpiceatannol
dc.subjectendoplasmic reticulum stress
dc.subjectapoptosis
dc.titleInvestigation of the Effects of Piceatannol on Endoplasmic Reticulum Stress on Brain in Rats with Experimental Subarachnoid Hemorrhage
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu