Investigation of the protective effects of piceatannol on experimental subarachnoid hemorrhage in rats

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dc.contributor.authorErbil, Guelfem
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:31:49Z
dc.date.available2025-01-27T20:31:49Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground Subarachnoid hemorrhage (SAH) is one of the most prevalent brain injuries in humans which has poor prognosis and high mortality rates. Due to several medical or surgical treatment methods, a gold standard method doesn't exist for SAH treatment. Piceatannol (PCN), a natural analog of resveratrol, was reported to reduce inflammation and apoptosis promising a wide range of therapeutic alternatives. In this study, we aimed to investigate the effects of PCN in an experimental SAH model. The alleviating effects of PCN in the hippocampus in an experimental SAH model were investigated for the first time. Methods and results In this study, 27 Wistar Albino male rats (200-300 g; 7-8 week) were used. Animals were divided into three groups; SHAM, SAH, and SAH + PCN. SAH model was created with 120 mu l of autologous arterial tail blood to prechiasmatic cisterna. 30 mg/kg PCN was administered intraperitoneally at 1st h after SAH. Neurological evaluation was performed with Garcia's score. RT-PCR was performed for gene expression levels in the hippocampus. Pyknosis, edema, and apoptosis were evaluated by H&E and TUNEL staining. Our results indicated that PCN administration reduced apoptosis (P < 0.01), cellular edema, and pyknosis (P < 0.05) in the hippocampus after SAH. Moreover, PCN treatment significantly decreased the expression levels of TNF-alpha (P < 0.01), IL-6 (P < 0.05), NF-kappa B (P < 0.05), and Bax (P < 0.05) in the hippocampus. Conclusions Our results demonstrated that PCN might be a potential therapeutic adjuvant agent for the treatment of early brain injury (EBI) following SAH. Further studies are required to clarify the underlying mechanisms and treatment options of SAH.
dc.description.sponsorshipanakkale Onsekiz Mart niversitesi
dc.description.sponsorshipThis article was partly produced from the master of science thesis of the first author.
dc.identifier.doi10.1007/s11033-024-09275-1
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue1
dc.identifier.pmid38409545
dc.identifier.scopus2-s2.0-85185963995
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11033-024-09275-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23279
dc.identifier.volume51
dc.identifier.wosWOS:001171803700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSubarachnoid hemorrhage
dc.subjectPiceatannol
dc.subjectApoptosis
dc.subjectInflammation
dc.subjectEdema
dc.subjectPyknosis
dc.subjectHippocampus
dc.titleInvestigation of the protective effects of piceatannol on experimental subarachnoid hemorrhage in rats
dc.typeArticle

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