Organic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications

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dc.authorid0009-0008-4896-5553en_US
dc.authorid0000-0003-2547-6120en_US
dc.authorid0000-0003-3445-1814en_US
dc.authorscopusid-en_US
dc.authorscopusid-en_US
dc.authorscopusid36088908700en_US
dc.authorwosidJPW-9304-2023en_US
dc.authorwosid-en_US
dc.authorwosidM-2907-2016en_US
dc.contributor.authorYıldız, Safiye Nur
dc.contributor.authorSezgin Arslan, Tugba
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2024-02-21T07:47:45Z
dc.date.available2024-02-21T07:47:45Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractTherapeutic angiogenesis is pivotal in creating effective tissue-engineered constructs that deliver nutrients and oxygen to surrounding cells. Hence, biomaterials that promote angiogenesis can enhance the efficacy of various medical treatments, encompassing tissue engineering, wound healing, and drug delivery systems. Considering these, we propose a rapid method for producing composite silicon-boron-wool keratin/jellyfish collagen (Si-B-WK/JFC) inorganic-organic biohybrid films using sol-gel reactions. In this approach, reactive tetraethyl orthosilicate and boric acid (pKa ⩾ 9.24) were used as silicon and boron sources, respectively, and a solid-state gel was formed through the condensation reaction of these reactive groups with the keratin/collagen mixture. Once the resulting gel was thoroughly suspended in water, the films were prepared by a casting/solvent evaporation methodology. The fabricated hybrid films were characterized structurally and mechanically. In addition, angiogenic characteristics were determined by the in ovo chick chorioallantoic membrane assay, which revealed an increased vascular network within the Si-B-WK/JFC biohybrid films. In conclusion, it is believed that Si-B-WK/JFC biohybrid films with mechanical and pro-angiogenic properties have the potential to be possessed in soft tissue engineering applications, especially wound healing.en_US
dc.identifier.citationYıldız, S.N., Sezgin Arslan, T., & Arslan, Y.E. (2024) Organic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications. Biomedical Materials, 19(2), 1-13. doi: 10.1088/1748-605X/ad2557en_US
dc.identifier.doi10.1088/1748-605X/ad2557
dc.identifier.endpage13en_US
dc.identifier.issn1748-6041
dc.identifier.issn1748-605X
dc.identifier.issue2en_US
dc.identifier.pmid38306684
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ad2557
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5738
dc.identifier.volume19en_US
dc.identifier.wosWOS:001161722600001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldız, Safiye Nur
dc.institutionauthorSezgin Arslan, Tugba
dc.institutionauthorArslan, Yavuz Emre
dc.language.isoen
dc.publisherIOP Publishingen_US
dc.relation.ispartofBiomedical Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectCAM assayen_US
dc.subjectBoronen_US
dc.subjectJellyfish collagenen_US
dc.subjectOrganic-inorganic biohybriden_US
dc.subjectRegenerative medicineen_US
dc.subjectSol-gelen_US
dc.subjectWool keratinen_US
dc.titleOrganic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications
dc.typeArticle

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