Evaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss

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dc.authoridBakirdogen, Serkan/0000-0002-3448-0490
dc.authoridCaglar Cil, ozge/0000-0001-8737-2891
dc.contributor.authorCil, Ozge Caglar
dc.contributor.authorBakirdogen, Serkan
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorGul, Hasan
dc.contributor.authorOymak, Sibel
dc.date.accessioned2025-01-27T20:29:00Z
dc.date.available2025-01-27T20:29:00Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The objective of this study was to evaluate the levels of von Willebraund Factor (vWF) in plasma and the protein/creatinine ratio in urine in patients with idiopathic sudden acute hearing loss, which we think to be caused by epithelial dysfunction. Materials-Methods: Thirty patients with a sudden hearing loss and thirty healthy individuals were included in the study. Before the treatment, blood and urine were collected from the patients and the control group to investigate the levels of the protein/creatinine ratio and the levels of vWF. The test results of the patients group were compared with those of the control group. Results: We found that the levels of vWF increased in the patient group, which was statistically significant (P <.05). The protein/creatinine ratio in the urine increased in the patient group, but this was not statistically significant (P >.05). In addition, we found that the vWF and urine protein/creatin ratio of the patients who benefited from treatment were lower than those who did not benefit. Conclusions: This study showed that sudden sensorineural hearing loss may result from endothelial dysfunction. However, more studies that include more patients are needed in order to support this. (c) 2022 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Otorrinolaringolog ' ia y Cirug ' ia de Cabeza y Cuello.
dc.identifier.doi10.1016/j.otorri.2022.09.002
dc.identifier.endpage282
dc.identifier.issn0001-6519
dc.identifier.issn1988-3013
dc.identifier.issue5
dc.identifier.pmid36427796
dc.identifier.scopus2-s2.0-85171258548
dc.identifier.scopusqualityQ3
dc.identifier.startpage277
dc.identifier.urihttps://doi.org/10.1016/j.otorri.2022.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22775
dc.identifier.volume74
dc.identifier.wosWOS:001169864100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Espana Slu
dc.relation.ispartofActa Otorrinolaringologica Espanola
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSensorineural hearing loss
dc.subjectProtein/creatinine ratio
dc.subjectvWf
dc.titleEvaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss
dc.title.alternativeEvaluación del Factor Von Willebraund y la Relación Proteína/Creatinina en la Hipoacusia Súbita Idiopática
dc.typeArticle

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