Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage

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dc.authorid0000-0002-6567-6218en_US
dc.authorid0000-0002-1373-6311en_US
dc.authorid0000-0001-8740-6422en_US
dc.authorid0000-0002-6094-4754en_US
dc.authorid0000-0002-1272-9654en_US
dc.authorscopusid23666636900en_US
dc.authorscopusid57191922068en_US
dc.authorscopusid55897728300en_US
dc.authorscopusid58145964000en_US
dc.authorscopusid8388590800en_US
dc.authorwosidIVV-5199-2023en_US
dc.authorwosidAFK-7508-2022en_US
dc.authorwosidAGT-5201-2022en_US
dc.authorwosid-en_US
dc.authorwosidAAV-9334-2021en_US
dc.contributor.authorAkar, Ali
dc.contributor.authorÖztopuz, Rahime Özlem
dc.contributor.authorBüyük, Başak
dc.contributor.authorOvalı, Mehmet Akif
dc.contributor.authorAykora, Damla
dc.contributor.authorMalçok, Ümit Ali
dc.date.accessioned2023-08-24T08:09:13Z
dc.date.available2023-08-24T08:09:13Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractSubarachnoid hemorrhage (SAH) accounts for 5% of all stroke cases and is responsible for significant permanent brain and neurological damage within the first few days. Loss of smell is one of those neurological disorders following olfactory bulb injury after SAH. Olfaction plays a critical role in several aspects of life. The primary underlying mechanism of olfactory bulb (OB) injury and loss of smell after SAH remains unknown. Piceatannol (PIC), a natural stilbene, possesses anti-inflammatory and anti-apoptotic effects against various diseases. In this study, we aimed to investigate the potential therapeutic effects of PIC on OB injury following SAH at molecular mechanism based on SIRT1, inflammatory (TNF-α, IL1-β, NF-κB, IL–6, TLR4), and apoptosis (p53, Bax, Bcl-2, caspase-3)-related gene expression markers and histopathology level; 27 male Wistar Albino rats were used in a pre-chiasmatic subarachnoid hemorrhage model. Animals were divided into groups (n = 9): SHAM, SAH, and PIC. Garcia’s neurological examination, brain water content, RT-PCR, histopathology, and TUNEL analyses were performed in all experimental groups with OB samples. Our results indicated that PIC administration significantly suppressed inflammatory molecules (TNF-α, IL–6, IL1-β, TLR4, NF-κB, SIRT1) and apoptotic molecules (caspase-3, p53, Bax). We also evaluated edema levels and cell damage in OB injury after SAH. Ameliorative effects of PIC are also observed at the histopathology level. Garcia’s neurological score test performed a neurological assessment. This study is the first to demonstrate the neuroprotective effects of PIC on OB injury after SAH. It suggests that PIC would be a potential therapeutic agent for alleviating OB injury after SAH.en_US
dc.identifier.citationAkar, A., Öztopuz, R. Ö., Büyük, B., Ovalı, M. A., Aykora, D., & Malçok, Ü. A. (2023). Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage. Molecular Neurobiology, 60(7), 3695–3706. https://doi.org/10.1007/s12035-023-03306-xen_US
dc.identifier.doi10.1007/s12035-023-03306-x
dc.identifier.endpage3706en_US
dc.identifier.issn0893-7648
dc.identifier.issn1559-1182
dc.identifier.issue7en_US
dc.identifier.pmid36933146
dc.identifier.scopus2-s2.0-85150291789
dc.identifier.startpage3695en_US
dc.identifier.urihttps://doi.org/10.1007/s12035-023-03306-x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4516
dc.identifier.volume60en_US
dc.identifier.wosWOS:000954499100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkar, Ali
dc.institutionauthorÖztopuz, Rahime Özlem
dc.institutionauthorOvalı, Mehmet Akif
dc.institutionauthorAykora, Damla
dc.institutionauthorMalçok, Ümit Ali
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnosmiaen_US
dc.subjectNeuro-inflammationen_US
dc.subjectOlfactory bulben_US
dc.subjectPiceatannolen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.titleNeuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage
dc.typeArticle

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