Circadian Rhythm and Leptin Hormone Responses to Nutritional Restriction in Gerbils (Meriones unguiculatus) with Suprachiasmatic Nucleus Lesions

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dc.contributor.authorGündüz, Bülent
dc.contributor.authorÖnder, Betül
dc.contributor.authorEkin, Ahmet
dc.contributor.authorHasanoğlu, Nursel
dc.date.accessioned2025-01-27T18:59:16Z
dc.date.available2025-01-27T18:59:16Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractRhythmically-regulated feeding behavior is in harmony with physiologic and metabolic activities in mammals. This rhythmic regulation is orchestrated by Suprachiasmatic Nucleus (SCN). However, it is not entirely clear how the SCN, which generates endogenous (internal) rhythms, influences body weight and serum leptin profile with activity rhythms in relation to feeding timing. In this study, animals in long photoperiod (14L:10D) were divided into two groups as control (sham-SCNx) and SCN lesions (SCNx). Then, these groups were split into four separate subgroups: a) ad libitum feeding; b) feeding only during the dark phase; c) feeding only during the light phase; and d) feeding during a specific period of the day (11:00-14:00 h). Locomotor activity and leptin hormone changes were observed in animals fed in cages attached to activity wheels for one month. Under the conditions of food restriction, the locomotor activities of the groups with SCNx and sham-SCNx demonstrated a phase shift toward the time of feeding. Serum leptin level did not change with feeding conditions but decreased in lesioned groups (SCNx). In conclusion, nutritional restriction caused phase shifts in activity rhythms and it was found that the SCN in gerbils was in charge of these rhythmic changes in the presence and absence of nutrients. © 2023, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.
dc.description.sponsorshipÇanakkale Onsekiz Mart Üniversitesi, ÇOMÜ, (BAP-2012/051); Çanakkale Onsekiz Mart Üniversitesi, ÇOMÜ
dc.identifier.doi10.31594/commagene.1378509
dc.identifier.endpage126
dc.identifier.issn2602-456X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85181871570
dc.identifier.scopusqualityQ4
dc.identifier.startpage119
dc.identifier.trdizinid1220845
dc.identifier.urihttps://doi.org/10.31594/commagene.1378509
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1220845
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13209
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherABADER (Adıyaman Bilimsel Arastırmalar Dernegi)
dc.relation.ispartofCommagene Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectActivity; biological clock; body weight; feeding
dc.titleCircadian Rhythm and Leptin Hormone Responses to Nutritional Restriction in Gerbils (Meriones unguiculatus) with Suprachiasmatic Nucleus Lesions
dc.title.alternativeBesin Kısıtlaması Uygulanan Suprakiazmatik Nükleus Lezyonlu Gerbillerde (Meriones unguiculatus) Sirkadiyen Ritim ve Leptin Hormon Yanıtları
dc.typeArticle

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