Development of ultra-sensitive and selective molecularly imprinted polymer-based electrochemical sensor for L-lactate detection

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dc.authoridSezgintürk, Mustafa Kemal / 0000-0003-3042-1087
dc.contributor.authorPişkin, Ensar
dc.contributor.authorÇetinkaya, Ahmet
dc.contributor.authorEryaman, Zulal
dc.contributor.authorKaradurmuş, Leyla
dc.contributor.authorÜnal, Mehmet Altay
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.contributor.authorHizal, Julide
dc.date.accessioned2025-01-27T20:46:12Z
dc.date.available2025-01-27T20:46:12Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLactate detection is important for the food and healthcare industries, and it's especially important when there's tissue hypoxia, hepatic illness, bleeding, respiratory failure, or sepsis. A new molecularly imprinted polymer (MIP) based electrochemical sensor was fabricated for differential pulse voltammetric assay of L-lactate (LAC). By using ZIF-8@ZnQ nanoparticles, the number of regions and effective surface area were increased. The polymeric film was obtained using 4 aminobenzoic acid (4-ABA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, 2-hydroxyethyl methacrylate (HEMA) as basic monomers, and 2-hydroxy-2-methylpropiophenone one as initiator. The developed 4-ABA/LAC/ZIF-8@ZnQ@MIP-GCE was morphologically characterised using SEM and electrochemically using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) measurements. A linear range of 0.1-1.0 pM LAC with a detection limit of 29.9 fM was found. Lastly, the MIP-based electrochemical sensor detected LAC in commercial human serum samples.
dc.description.sponsorshipScientific and Technological Research Council of Trkiye (TUBITAK); ARDEB/1004-Center of Excellence Support Program [20AG003]; Scientific and Technological Research Council of Trkiye (TUBITAK) under the ARDEB/1004-Center of Excellence Support Program [20AG003]
dc.description.sponsorshipThis study is produced from the Development of new analytic tools and pathways to accelerate diagnosis and diagnostic monitoring of rare diseases: Metabolic test in vivo for Malignant Hyperthermia project, and the authors are grateful for the financial support from THE SCI-ENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TUERKIcenter dotYE (TUBITAK) Project Number 123N049. Ahmet Cetinkaya, thanks to hisgrant from the Scientific and Technological Research Council of Tuerkiye (TUBITAK) under the BIDEB/2218-National Postdoctoral Research Scholarship Program and ARDEB/1004-Center of Excellence Support Program (Project No: 20AG003) . Ensar Piskin thanks the grant from the Scientific and Technological Research Council of Tuerkiye (TUBITAK) under the ARDEB/1004-Center of Excellence Support Program (Project No: 20AG003) .r grant from the Scientific and Technological Research Council of Turkiye (TUBITAK) under the BIDEB/2218-National Postdoctoral Research Scholarship Program and ARDEB/1004-Center of Excellence Support Program (Project No: 20AG003) . Ensar Piskin thanks the grant from the Scientific and Technological Research Council of Turkiye (TUBITAK) under the ARDEB/1004-Center of Excellence Support Program (Project No: 20AG003) .
dc.identifier.doi10.1016/j.microc.2024.111163
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85198249476
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2024.111163
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24834
dc.identifier.volume204
dc.identifier.wosWOS:001271925700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMolecularly imprinted polymers
dc.subjectL-lactate
dc.subjectVoltammetry
dc.subjectPhotopolymerization
dc.subjectNanoparticle
dc.titleDevelopment of ultra-sensitive and selective molecularly imprinted polymer-based electrochemical sensor for L-lactate detection
dc.typeArticle

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