Development of ultra-sensitive and selective molecularly imprinted polymer-based electrochemical sensor for L-lactate detection
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Lactate detection is important for the food and healthcare industries, and it's especially important when there's tissue hypoxia, hepatic illness, bleeding, respiratory failure, or sepsis. A new molecularly imprinted polymer (MIP) based electrochemical sensor was fabricated for differential pulse voltammetric assay of L-lactate (LAC). By using ZIF-8@ZnQ nanoparticles, the number of regions and effective surface area were increased. The polymeric film was obtained using 4 aminobenzoic acid (4-ABA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, 2-hydroxyethyl methacrylate (HEMA) as basic monomers, and 2-hydroxy-2-methylpropiophenone one as initiator. The developed 4-ABA/LAC/ZIF-8@ZnQ@MIP-GCE was morphologically characterised using SEM and electrochemically using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) measurements. A linear range of 0.1-1.0 pM LAC with a detection limit of 29.9 fM was found. Lastly, the MIP-based electrochemical sensor detected LAC in commercial human serum samples.
Açıklama
Anahtar Kelimeler
Molecularly imprinted polymers, L-lactate, Voltammetry, Photopolymerization, Nanoparticle
Kaynak
Microchemical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
204
