The Influences of Metformin on Prostate in Terms of PSA Level and Prostate Volume

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dc.authorid0000-0002-1040-3255en_US
dc.authorscopusid56500220800en_US
dc.authorwosidABF-4291-2021en_US
dc.contributor.authorAtalay, Eray
dc.contributor.authorDemir, Aslan
dc.contributor.authorEroğlu, Hüseyin Avni
dc.date.accessioned2023-07-24T12:46:07Z
dc.date.available2023-07-24T12:46:07Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose: The effects of metformin on prostate volume and prostate-specific antigen (PSA) were investigated. Materials and Methods: We enrolled 384 newly diagnosed diabetes mellitus (DM) patients and 152 controls all of whom were >50 years into our prospective cross-sectional observational study. The first group contained patients receiving metformin only, the second group patients were taking a mixture of medications, including metformin plus other oral anti-diabetics, and the third was the control group. Before beginning treatment, body mass indices (BMI) of all cases were obtained. Prostate volumes were evaluated using transabdominal ultrasonography at the sixth and twelfth months. Insulin, glycosylated hemoglobin (HbA1C), insulin sensitivity index (ISI), insulin- rich growth factor (IGF-1), PSA, free PSA, and total testosterone levels were measured. Results: The differences in BMI between the first and third groups were statistically significant (P < 0.05). There were no statistical differences among the groups in terms of prostate volumes (P > 0.05). The differences between the groups for insulin, HbA1C, ISI, IGF-1 (somatomedin), PSA, free PSA, and total testosterone levels were not statistically significant (P > 0.05). Free PSA and total testosterone levels in groups 1 and 2 were not statistically different at the beginning of treatment and the sixth month (p >0.05), but within groups 1 and 2, only PSA levels were different at the start of the study until completion. No differences were seen in the third group. Conclusion: Metformin appears to cause a decrease in PSA levels. The mechanism and any effects on prostate tissue will be studied in future randomized, prospective studies.en_US
dc.identifier.citationAtalay, E., Demir, A., & Eroğlu, H. A. (2021). The influences of metformin on prostate in terms of PSA level and prostate volume. Urology Journal, 18(2), 181-185. doi:10.22037/uj.v16i7.5645en_US
dc.identifier.doi10.22037/uj.v16i7.5645
dc.identifier.endpage185en_US
dc.identifier.issn1735-1308
dc.identifier.issn1735-546X
dc.identifier.issue2en_US
dc.identifier.pmid32748391
dc.identifier.scopus2-s2.0-85106068717
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.22037/uj.v16i7.5645
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4442
dc.identifier.volume18en_US
dc.identifier.wosWOS:000646926000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEroğlu, Hüseyin Avni
dc.language.isoen
dc.publisherUrology and Nephrology Research Centreen_US
dc.relation.ispartofUrology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetforminen_US
dc.subjectProstateen_US
dc.subjectProstate biopsyen_US
dc.subjectPSAen_US
dc.titleThe Influences of Metformin on Prostate in Terms of PSA Level and Prostate Volume
dc.typeArticle

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