Melatonin-leptin interaction and obesity-related genes

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dc.authoridGündüz, Bülent / 0000-0003-0497-8287
dc.contributor.authorGündüz, Bülent
dc.contributor.authorBalkan, Emine İnci
dc.date.accessioned2025-05-29T02:54:07Z
dc.date.available2025-05-29T02:54:07Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMost living organisms have circadian clocks which maintain rhythm in internal cycles of behavior, physiology, and metabolism, allowing them to anticipate the earth's 24hour rotation. In mammals, circadian integration of metabolic systems optimizes energy gathering and usage across the light and dark cycles. Disruption of circadian rhythms may lead to metabolic dysfunctions such as obesity and obesity-related disorders. The molecular and hormonal mechanism behind obesity is mostly related to mRNA expressions in hypothalamus, and leptin, and melatonin hormone levels. In obesity and related disorders, the chronobiotic hormone melatonin regulates physiological functions such as energy metabolism, body fat, and reproduction by cross-interacting with leptin. Leptin signals satiety by inhibiting Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP genes in hypothalamus and exerts its effects on food intake, body weight, and the reproductive system. In this review, the molecular and hormonal mechanisms behind obesity were discussed. © 2025 Gündüz & Balkan.
dc.identifier.doi10.23902/trkjnat.1619680
dc.identifier.endpage102
dc.identifier.issn2147-0294
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105003835222
dc.identifier.scopusqualityN/A
dc.identifier.startpage93
dc.identifier.urihttps://doi.org/10.23902/trkjnat.1619680
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29949
dc.identifier.volume26
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTrakya University
dc.relation.ispartofTrakya University Journal of Natural Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250529
dc.subjectAgouti-Related Protein (AgRP)
dc.subjectEndocrine
dc.subjectGene Expression
dc.subjectNeuropeptide Y (NPY)
dc.subjectSuprachiasmatic Nuclei (SCN)
dc.titleMelatonin-leptin interaction and obesity-related genes
dc.typeReview

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